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The flavivirus receptor-binding domain has been putatively assigned to a hydrophilic region (FG loop) in the envelope (E) protein. In some flaviviruses this domain harbors the integrin-binding motif Arg-Gly-Asp (RGD). One of us has shown earlier that host cell adaptation of Murray Valley encephalitis virus (MVE) can result in the selection of attenuated variants altered at E protein residue Asp...
BACKGROUND The etiologic profile of community-acquired pneumonia (CAP) for each age group could be similar among inpatients and outpatients. This fact brings up the link between etiology of CAP and its clinical evolution and outcome. Furthermore, the majority of pneumonia etiologic studies are based on hospitalized patients, whereas there have been no recent population-based studies encompassin...
A high-speed interface has been designed for interconnection of the S/390 I/O subsystem to the IBM S/390 G5 processor. The self-timed interface (STI) provides high bandwidth, greater communication distances, and simpler timing within the S/390 servers than traditional interfaces. The STI communicates between the memory bus adapter and the expanded S/390 I/O subsystem, which now includes the new...
The CMOS-based IBM S/390 Parallel Enterprise Servers have always employed the technique of memory caching to bridge the gap between processor speed and mainmemory access time. However, that gap has widened with each succeeding system generation, requiring increasingly sophisticated, multiple-level cache structures in order to minimize memory-access latency. The IBM S/390 G5 and G6 include two-l...
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