نتایج جستجو برای: 375

تعداد نتایج: 6827  

2017
Imane Song Sarah Roels Geert A Martens Luc Bouwens

OBJECTIVE Previous studies demonstrated that circulating microRNA-375 (miR-375) is a suitable plasma biomarker for real-time detection of beta cell death. The present study evaluated the use of this biomarker to assess the beta cytoprotective effect of phenylpropenoic acid glucoside (PPAG), which was previously demonstrated to protect beta cells against various types of injury, and of exendin-4...

Journal: :Molecular and cellular biology 2010
Kotb Abdelmohsen Emmette R Hutchison Eun Kyung Lee Yuki Kuwano Mihee M Kim Kiyoshi Masuda Subramanya Srikantan Sarah S Subaran Bernard S Marasa Mark P Mattson Myriam Gorospe

Neuronal development and plasticity are maintained by tightly regulated gene expression programs. Here, we report that the developmentally regulated microRNA miR-375 affects dendrite formation and maintenance. miR-375 overexpression in mouse hippocampus potently reduced dendrite density. We identified the predominantly neuronal RNA-binding protein HuD as a key effector of miR-375 influence on d...

Journal: :Anglia - Zeitschrift für englische Philologie 1889

2014
Xiangyun Chang Siyuan Li Jun Li Liang Yin Ting Zhou Chen Zhang Xuan Chen Kan Sun

Han population is six times as likely as Kazak population to present with type 2 diabetes mellitus (T2DM) in China. We hypothesize that differential expression and CpG methylation of miR-375 may be an ethnic-related factor that influences the incidence of T2DM. The expression level of miR-375 was examined using real-time PCR on Kazak and Han T2DM plasma samples. Furthermore, the methylation lev...

2015
Lili Song Shikai Liu Saitian Zeng Liang Zhang Xia Li

BACKGROUND Prediction of radioresistance of HR-HPV-positive (+) cervical cancer, especially before the course of radiotherapy, is quite beneficial to develop an optimal treatment strategy for individual patients. Unfortunately, the mechanisms responsible for radioresistance of cervical cancer are still largely unexplored. HR-HPV infection leads to a series of changes to normal biophysical proce...

2017
Tianhao Sun Chen-Tian Li Lifeng Xiong Ziyu Ning Frankie Leung Songlin Peng William W Lu

Wnt signaling pathways are essential for bone formation. Previous studies showed that Wnt signaling pathways were regulated by miR-375. Thus, we aim to explore whether miR-375 could affect osteogenesis. In the present study, we investigated the roles of miR-375 and its downstream targets. Firstly, we revealed that miR-375-3p negatively modulated osteogenesis by suppressing positive regulators o...

Journal: :Oncology reports 2016
Fengyun Cui Shuyang Wang Iweng Lao Chunxian Zhou Hui Kong Nayima Bayaxi Jiali Li Qi Chen Tengfang Zhu Hongguang Zhu

Accumulating evidence has shown that aberrantly expressed microRNAs (miRNAs) are associated with tumor development and progression. Our previous study found that microRNA-375 (miR-375) was downregulated in colorectal cancer (CRC), but little is known concerning the role of miR-375 and the related mechanism in CRC development. The proliferation, invasion and migration effects were investigated b...

2012
Tali Avnit-Sagi Tal Vana Michael D. Walker

MicroRNAs (miRNAs) are a class of small non-coding RNAs that play an important role in mediating a broad and expanding range of biological activities. miR-375 is expressed selectively in the pancreas. We have previously shown that selective expression of miR-375 in pancreatic beta cells is controlled by transcriptional mechanisms operating through a TATA box-containing promoter. Expression of m...

Journal: :The EMBO journal 2004
Stefan Schulz Dana Mayer Manuela Pfeiffer Ralf Stumm Thomas Koch Volker Höllt

Morphine is a poor inducer of micro-opioid receptor (MOR) internalization, but a potent inducer of cellular tolerance. Here we show that, in contrast to full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO), morphine stimulated a selective phosphorylation of the carboxy-terminal residue 375 (Ser(375)). Ser(375) phosphorylation was sufficient and required for morphine-induced desens...

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