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Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during osteoclast differentiation has not yet been clearly established. Tartrate-resi...
A hash table is a commonly used data structure to store a set of items, allowing fast inserts, lookups and deletes. Every item consists of a unique identifier called a key and a piece of information. For example, the key might be a Social Security Number, a driver’s licence number, or an employee ID number. For our purposes, we focus only on the key. Recall that the operations we would like to ...
The emergence of the web and the explosion of digital data of various forms has created the need for very efficient algorithms to deal with large data sets. A search engine is a good example of an application that needs to efficiently process very large amounts of data. Think about processing query logs to compute statistical information about the queries (e.g. the number of distinct queries), ...
Studies have shown the prognostic significance of disseminated tumor cells (DTC) in bone marrow of patients with colorectal cancer. However, the molecular characteristics of DTCs, including their miRNA expression profiles, remain mostly unknown. In this study, we analyzed the miRNA expression of DTCs in bone marrow. EpCAM(+) bone marrow cells were collected using immunomagnetic beads after excl...
BACKGROUND Seafood is the predominant source of omega-3 fatty acids, which are essential for optimum neural development. However, in the USA, women are advised to limit their seafood intake during pregnancy to 340 g per week. We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal s...
BACKGROUND Most neuroendocrine tumors express chromogranin A (CgA). The posttranslational processing of neuroendocrine proteins such as CgA is often specific for the individual tumor. To cope with this variability and improve tumor diagnosis, we developed a processing-independent analysis (PIA) method to measure the total CgA product. METHODS For PIA, samples underwent trypsin treatment follo...
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