Anthracyclines, a large group of quinonoid compounds, are used to treat some forms of cancer. Although highly effective in cancer therapy, the mechanism of action of these compounds is not specific; they act on cancer and other cells by numerous mechanisms. A new anticancer quinone (HU-331) was synthesized from cannabidiol. It shows significant high efficacy against human cancer cell lines in v...

Let µ 1 (G) ≥. .. ≥ µn (G) be the eigenvalues of the adjacency matrix of a graph G of order n, and G be the complement of G. Suppose F (G) is a fixed linear combination of µ i (G) , µ n−i+1 (G) , µ i G ¡ , and µ n−i+1 G ¡ , 1 ≤ i ≤ k. It is shown that the limit lim n→∞ 1 n max {F (G) : v (G) = n} always exists. Moreover, the statement remains true if the maximum is taken over some restricted fa...

Si(331)-(12x1) is the only confirmed planar silicon surface with a stable reconstruction located between (111) and (110). We have optimized the annealing sequence and are able to obtain almost defect free, atomically precise surface areas approaching micrometer dimensions. The unprecedented perfection of the surface combined with its pronounced structural anisotropy makes it a promising candida...

By making a renormalization group analysis we explore the possibility of having a 331 model as the only intermediate gauge group between the standard model and the scale of unification of the three coupling constants. We shall assume that there is no necessarily a group of grand unification at the scale of convergence of the couplings. With this scenario, different 331 models and their correspo...

We calculate the exact tree-level scalar mass matrices resulting from symmetry breaking using the most general gauge-invariant scalar potential of the 331 model, both with and without the condition that lepton number is conserved. Physical masses are also obtained in some cases, as well as couplings to standard and exotic gauge bosons.

about 38% for females and 28% for males. In an ongoing study, mice are being fed rapamycin beginning at 270 days, with a significant increase in survival also being apparent in this cohort. Rapamycin was first identified as a natural product of the bacterium Streptomyces hygroscopicus in soil samples from Easter Island — famous for its impressive rock-carved human statues (Fig. 1). The compound...

Two parameters are commonly used for the evaluation of antibiotic efficacy in animal models: bacterial counts in tissue fluids and survival rate. The second parameter is easy to assess and seems more relevant from the clinical perspective; a curative dose is used as a reliable end-point for showing subtle differences in antibiotic behaviour. Reduction in bacterial counts provides information on...

Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as "331" selectively induced cell death in glioma cells but not in astrocytes. Compound 331 upregulated miR-494 and downregulated CDC20 in glioma cells b...