background and aims: pelvic organ prolapse (pop) is a common condition which affects on a large proportion of women. the objective of this study was to determine the risk factors of pop in iranian women. methods: this cross-sectional study was carried out to examine the role of demographic, anthropometric and clinical characteristics in pop disease in a sample of 365 females in ilam, iran. exam...

background sepsis can be defined as the body’s response to an infection. sepsis in children remains a significant cause of morbidity and mortality worldwide. objectives this study focuses on the etiological factors, risk factors, and clinical characteristics of sepsis in neonate and pediatric patients. patients and methods a prospective study was conducted over a six-month period in the pediatr...

organ donation is an integral part of the health care system. many patients who have had an accident or have undergone a progressive disease are in need of an organ transplant and if they do not receive the required organ they would die. it is important to know that the most important source of organ donation is the brain death patients. it is highly essential to determine the pivotal factors t...

conclusions there was a significant correlation between elevated lipase levels and the incidence of multiple organ failure. moreover, no significant association was found between the elevated amylase levels and organ failure. however, on admission, measurement of these enzymes coupled with routine laboratory investigations can be a powerful tool in the early detection of patients progressing to...

hydrocarbons are ubiquitous in daily life and include plant and animal fats, alcohols, solvents, natural gas, petroleum derivates. majority of intoxication reports of hydrocarbons are due to inhalation or ingestion, but there is few reports about intravenous injection of gasoline. we report a 58 year-old man who injected gasoline intravenously for suicide. he developed soft tissue necrosis of f...

background: confrontation with the consequences of diabetes causes a crisis in physical, mental, and spiritual dimensions. sometimes the spiritual crisis can be tremendous. since spiritual health coordinates different aspects of human life, this study aimed to identify the spiritual health of patients with defects caused by diabetes. materials and methods: this was a qualitative-phenomenologica...

Mature microRNAs (miRNAs) are single-stranded RNAs of 18-24 nucleotides that repress post-transcriptional gene expression. However, it is unknown whether the functions of mature miRNAs can be regulated. Here we report that expression of versican 3'UTR induces organ adhesion in transgenic mice by modulating miR-199a* activities. The study was initiated by the hypothesis that the non-coding 3'UTR...

14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3ɛ or ...