1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...

When I was an undergraduate at Caltech, I worked in Bob Edgar’s laboratory on an obscure aspect of phage T4 morphogenesis, which had previously been studied by a little-known South African geneticist, Sydney Brenner [1]. I remember a journal club presented by one of the graduate students in the lab, about the lac repressor binding to DNA. I don’t remember the precise experiments but I know I wa...

Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around globe. In this disease, chondrocytes responsible for growth and maintenance articular joints start to deplete due rogue involvement phosphoinositide 3-kinase, protein kinase-B p38 mitogenactivated kinases. Presently, there are medications providing symptomatic treatment, however, they cannot t...

Integrin linked kinase (ILK) is a serine/threonine protein kinase implicated in the phosphatidylinositol 3’kinase (PI3’K) pathway. Integrin linked kinase has been investigated in different organisms such as mammalian systems (human, mice, rat), insects (Drosophila) and nematodes (Cenorhabditis elegans), however to date little data regarding ILK research on amphibians has been reported. In...

Neochamaejasmin A is an individual compound isolated from Stellera chamaejasme and exerts antitumor effects on several types of human cancer cells. However, the effect neochamaejasmin osteosarcoma cells has not yet been investigated. The main aim was to detect in vitro MG-63 were treated with different concentrations (20, 40, 80 μg/ml). Cell viability detected by 3-(4,5-dimethylthiazol-2-yl)-2,...