Sulfuric acid functionalized magnetic nanocatalyst (SAMNC) has been prepared as an efficientacidic and applied in the one-pot preparation of 2,3-dihydroquinazolin-4 (1H) -one derivatives.This catalyst has been characterized by FT-IR, SEM, and VSM. According to the obtainedresults, including time, yield and recyclability, SAMNC could be considered as an efficient catalystfor organic transformati...

The base catalyzed intramolecular nucleophilic cyclization of 1-(2-bromobenzoyl)-3-(2-fluorophenyl)thiourea (1) in the presence of N,N-dimethyl formamide (DMF) afforded the 1-(3-fluorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (2) by an intramolecular nucleophilic substitution SNAr mechanism. The structure was supported by the spectroscopic data and unambiguously confirmed by the single c...

The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space gro...

Shiga-like toxins and ricin are ribosome-inactivating proteins (RIPs) that are lethal to mammals and pose a global health threat. No clinical vaccines or therapeutics currently exist to protect against these RIPs. Two small molecules (Retro-1 and Retro-2) were discovered with high-throughput screening and reported for their protection of cells against RIPs. Of great significance, Retro-2, repor...

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