OBJECTIVE(S) Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was inject...

2-Amino-3-functionally substituted thiophene de­ rivatives are important intermediates to the phar­ maceutically important thieno[2,3-d]pyrimidines [2]. These thiophene derivatives were available from the procedures published by K. Gewald [3, 4] via either the reaction of a-methylene ketones with active methylene nitriles in presence of elementary sulphur of from a-mercaptoketones and active me...

A series of hydrazones were synthesized by condensing substituted hydrazides with appropriate carbonyl compounds. The chemical structures the compounds confirmed infrared, proton nuclear magnetic resonance, carbon-13 mass ((4-chloro-phenylamino)-acetic acid [1-(4-chlorophenyl)-phenyl-methylene]-hydrazide and (2,4-dichloro-phenylamino)-acetic (3-oxo- 1,3-dihydro-indole-2-ylidene)-hydrazide only)...