The growth of large-area bilayer graphene has been of technological importance for graphene electronics. The successful application of graphene bilayers critically relies on the precise control of the stacking orientation, which determines both electronic and vibrational properties of the bilayer system. Toward this goal, an effective characterization method is critically needed to allow resear...

Stable isotope labeling (SIL) techniques have the potential to enhance different aspects of liquid chromatography-high-resolution mass spectrometry (LC-HRMS)-based untargeted metabolomics methods including metabolite detection, annotation of unknown metabolites, and comparative quantification. In this work, we present MetExtract II, a software toolbox for detection of biologically derived compo...

In recent years stable isotopes of metallic and semi-metallic elements have become popular as tracers in studies of nutrition and metabolism. There are several recent reviews on the use of stable isotopes of the mineral elements (Janghorbani & Young, 1980; Janghorbani et af . 1985). The orientation of these reviews has tended toward neutron-activation analysis in conjunction with the faecal iso...

Abstract This invited Team Profile was created by Shuo Wang, Igor Larrosa, Hideki Yorimitsu and Greg Perry. They recently published an article on carboxylic acid salts as dual-function reagents for carboxylation carbon isotope labeling. project brought together researchers based in Japan the UK, demonstrates how scientists with different cultural backgrounds can work to build powerful results. ...

A general and simple labeling method, termed glycan reductive isotope-coded amino acid labeling (GRIAL), was developed for mass spectrometry-based quantitative N-glycomics.

Many large, disease-related biobanks of serum samples have been established prior to the widespread use of proteomics in biomarker research. These biobanks may contain relevant information about the disease process, response to therapy or patient classifications especially with respect to long-term follow-up that is otherwise very difficult to obtain based on newly initiated studies, particular...

OBJECTIVE Several mouse models of cardiac neural crest cell (NCC)-associated conotruncal heart defects exist, but the specific cellular and molecular defects within cardiac NCC morphogenesis remain largely unknown. Our objective was to investigate the underlying mechanisms resulting in outflow tract defects and why insufficient cardiac NCC reach the heart of the Splotch (Sp(2H)) mouse mutant em...

Continuous isotope labeling and tracing is often needed to study the transformation, movement, and allocation of carbon in plant-soil systems. However, existing labeling methods have numerous limitations. The present study introduces a new continuous labeling method using naturally 13C-depleted CO2. We theoretically proved that a stable level of C-CO2 abundance in a labeling chamber can be main...

Isotopic composition of snow cover and streamflow was determined in a snowdominated, forested watershed to quantify the spatial variability and processes that alter stable isotope (oxygen-18, 18O and deuterium, 2H) composition under different forest canopy conditions (clear-cut, partial-cut (thinned), and unimpacted forest). Snow sampling was carried out on 4 days in late winter and early sprin...

The reaction of two D-amino acid oxidases from the yeasts Rhodotorula gracilis and Trigonopsis variabilis with the substrates alanine and valine in their 2-1H and 2-2H forms was studied employing the stopped-flow spectrophotometric technique. The turnover numbers at infinite substrate and oxygen concentrations were: 20,700/4,250 and 1,730/360 ([2-1H]/[2-2H]alanine and valine, respectively) for ...