Virtual screening (VS) can be accomplished in either ligand- or structure-based methods. In recent times, an increasing number of 2D fingerprint and 3D shape similarity methods have been used in ligand-based VS. To evaluate the performance of these ligand-based methods, retrospective VS was performed on a tailored directory of useful decoys (DUD). The VS performances of 14 2D fingerprints and f...

OBJECTIVES To evaluate the potential use of a novel 3D turbo spin-echo (TSE) T2-weighted (T2w) technique for assessing the vessel wall in the superficial femoral artery at 3.0 T. BACKGROUND Magnetic resonance imaging can be used for the noninvasive assessment of atherosclerotic plaque burden in the peripheral circulation. Although black-blood 2D TSE techniques have been used for femoral arter...

OBJECTIVE To assess the effect of vision in three dimensions (3D) versus two dimensions (2D) on mental workload and laparoscopic performance during simulation-based training. MATERIALS AND METHODS A prospective, randomized crossover study on inexperienced students in operative laparoscopy was conducted. Forty-six candidates executed five standardized exercises on a pelvitrainer with both visi...

Background: Setting up an in vitro follicle culture system that resembles in vivo ovary condition has high value in research. Additionally, expression evaluation of folliculogenesis involved genes could lead us to the designing of better culture system. Materials and Methods: ovaries of 12-day-old female NMRI mice were removed, 100-130 μm pre-antral follicles were mechanically isolated from fre...

BACKGROUND We sought to assess the long-term evolution of left ventricular (LV) function using two-dimensional (2D) and three-dimensional (3D) speckle tracking echocardiography (STE) for the detection of preclinical diabetic cardiomyopathy, in asymptomatic type 1 diabetic patients, over a 6-year follow-up. DESIGN AND METHODS Sixty-six asymptomatic type 1 diabetic patients with no cardiovascul...

background: tangential irradiation of intact breast is one of the most common procedures performed in any radiotherapy center. this method is performed by using 2d and 3d treatment planning. the aim of this study was to compare 2d with 3d plans in breast conserving radiotherapy. homogeneity of isodose, and lung received dose were compared. materials and methods: twenty patients with breast canc...

A two-step concept for 3D segmentation on 5 abdominal organs inside volumetric CT images is presented. Firsteach relevant organ’s volume of interest extracted as bounding box. The acts input asecond stage, wherein two compared U-Nets with different architectural dimensions re-construct an organ segmen-tation label mask. In this work, we focus comparing 2D vs. U-Net counterparts. Our initial res...

Objectives To evaluate the effectiveness of iodine-125 (125I) seed implantation for pancreatic cancer (PC), and preliminarily evaluate the clinical value of a self-developed three-dimensional (3D) visualized seed planning and navigation system in 125I seed implantation for treatment of PC. Patients and methods Our team retrospectively reviewed 25 PC patients who underwent 125I seed implantati...

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of ...