BACKGROUND To report on the trend in all-cause mortality in a rural district of Malawi that has successfully scaled-up HIV/AIDS care including antiretroviral treatment (ART) to its population, through corroborative evidence from a) registered deaths at traditional authorities (TAs), b) coffin sales and c) church funerals. METHODS AND FINDINGS Retrospective study in 5 of 12 TAs (covering appro...

Alzheimer's disease (AD), the most common form of dementia in the elderly, was found to exhibit a trend toward a higher risk in females than in males through epidemiological studies. Therefore, we hypothesized that gender-related genetic risks could exist. To reveal the ones for late-onset AD (LOAD), we extended our previous genetic work on chromosome 10q (genomic region, 60-107 Mb), and single...

BACKGROUND Occupational skin disease is a common problem among health care workers (HCWs). The prevalence of occupational skin disease in HCWs has been reported in several international studies, but not in the UK. AIMS To estimate the prevalence of occupational skin disease in a population of UK HCWs and to explore possible causative factors. METHODS Clinical and non-clinical HCWs attending...

While many studies have evaluated the effect of medications on semen quality, there is little guidance as to what is the true impact of many medications on male fertility. Further well designed studies are required to elucidate the precise associations between certain therapeutic medications and their effect on male fertility. *Corresponding author: Yulian Zhao, PhD, MD, MBA, Johns Hopkins Univ...

Abstract Some deer species are of conservation concern; others officially managed as a food source or for their trophies, whereas in many regions, regarded overabundant even nuisance causing damages. Regardless local management issues, most cases, reliable data on population sizes and sex ratios lacking. Non-invasive genetic approaches promising tools the estimation size structure. We developed...

AIMS We investigated the net benefit in the outcome of reducing treatment delay through field triage and emergency department (ED) bypass in patients with ST-elevation myocardial infarction (STEMI) treated with primary angioplasty. METHODS AND RESULTS In a prospective registry study, consecutive patients with suspected STEMI were assigned to: (i) pre-hospital ECG and triage or (ii) ECG and tr...

BACKGROUND Reperfusion of ischemic rat hearts in the presence of thrombin or norepinephrine but not endothelin-1 causes the generation of inositol 1,4,5-trisphosphate (Ins 1,4,5P3) and arrhythmias. The present study investigates the effect of endothelin-1 on these responses. METHODS AND RESULTS Ins 1,4,5P3 generation was quantified by use of [3H] labeling and high-performance liquid chromatog...

insulin resistance in middle-aged men. Arterioscler Thromb Vasc Biol 2006;26:2758–2762. 10. Patel S, Flyvbjerg A, Kozàkovà M, Frystyk J, Ibrahim IM, Petrie JR, Avery PJ, Ferrannini E, Walker M, the RISC Investigators. Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. Eur Heart J 2008;29:386–393. ...

bladder cancer risk. Cancer Res 1991;51:2762–7. 19. Lee DH, Yang SC, Hong SJ, Chung BH, Kim IY. Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes. Clin Cancer Res 1998;4:535–8. 20. Mostofi FK, Sobin LH, Torloni H. Histologic typing of urinary bladders. In: International histological classification of tumors. Geneva: World Health Organization, 1973:36. 21. S...