A mutation in codon 249 of the TP53 gene (249(Ser)), related to aflatoxin B(1) exposure, has previously been associated with hepatocellular carcinoma risk. Using a novel internal standard plasmid, plasma concentrations of 249(Ser)-mutated DNA were quantified by electrospray ionization mass spectrometry in 89 hepatocellular carcinoma cases, 42 cirrhotic patients, and 131 nonliver diseased contro...

OBJECTIVE(S) To obtain reliable information about the incidence of adverse drug reactions, and identify potential areas where intervention may reduce the burden of ill-health. DESIGN Prospective observational study. SETTING A large tertiary children's hospital providing general and specialty care in the UK. PARTICIPANTS All acute paediatric admissions over a one year period. MAIN EXPOSU...

A mutation in codon 249 of the TP53 gene (249), related to aflatoxin B1 exposure, has previously been associated with hepatocellular carcinoma risk. Using a novel internal standard plasmid, plasma concentrations of 249-mutated DNA were quantified by electrospray ionization mass spectrometry in 89 hepatocellular carcinoma cases, 42 cirrhotic patients, and 131 nonliver diseased control subjects, ...

The incidence of hepatocellular carcinomas (HCC) varies widely worldwide, with some of the highest incidence rates found in China. Chronic infection with the hepatitis B virus (HBV) and exposure to aflatoxins in foodstuffs are the main risk factors. A G to T transversion at codon 249 of the p53 gene (249(ser)) is commonly found in HCCs from patients in regions with dietary aflatoxin exposure. B...

Adult mosquito collections were conducted for 12 weeks in two residential areas in Kuala Lumpur. The CDC light traps were compared using dry ice and yeast as sources of carbon dioxide attractants for mosquitoes. The efficacy of the dry ice baited trap was significant over yeast generated CO2 trap. The predominant species obtained were Culex quinquefasciatus, Stegomyia albopicta and Armigeres su...

This paper presents the results of a study to assess feasibility using Structure from Motion photogrammetric method estimate what parts Wołek Castle have survived 15th century present day. The measurements were made with Nikon D5200 camera, and 249 mock-up images obtained. Planimetry altitude coordinates castle ruins obtained RTN GNSS polar method. in 2000 coordinate system zone 6, heights Kron...

ObjectivesTo verify the frequency of viruses causing acute gastroenteritis (AGE) in association with histo-blood group antigen (HBGA) and Rotarix™ vaccination coverage children from Amazon region.DesignFecal saliva samples were collected AGE (n = 485) respiratory infection (ARI) 249) clinical symptoms. Rotavirus A (RVA), norovirus, human adenovirus (HAdV), sapovirus (SaV) verified feces by mole...