Bone loss is induced in regucalcin transgenic rats. The role of exogenous regucalcin in the regulation of osteoblastic cell function was investigated. Osteoblastic MC3T3-E1 cells with subconfluent monolayers were cultured for 24-72 h in medium containing regucalcin (10(-10) or 10(-9) M) without fetal bovine serum. The presence of regucalcin did not have a significant effect on cell number. Cult...

Although the symptoms of a transient ischemic attack (TIA) by definition resolve completely, the subsequent risk of cardiovascular complications is substantial. Urgent diagnosis and start of secondary prevention can reduce these risks. In light of the potential unfavourable prognosis, especially the first days after a TIA, we have developed and implemented a 24/7 TIA-service. Patients can be re...

The C═N bond is a critical structural piece of many N-donor ligand scaffolds and central to the properties reactivity important coordination complexes. For example, units play key role in “redox non-innocence” α-diimine complexes making charge-transfer excited-state character available N-heterocyclic ligands such as bipyridine. In N-heterocycles like pyridine, benzannulation can be used extend ...

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In a three-component system containing dibenzo-24-crown-8 (1), diamino-dibenzo-24-crown-8 (2), and 1,2-bis(4,4(')-dipyridyl)ethane (3(2+)), axle 3(2+) can shuttle between wheels 1 and 2 by acid-base control, accompanying color changes from yellow to red. This system could not only be taken as a chromophoric supramolecular switch, but also exhibit a function as INHIBIT logic gate.

The title compound, C(19)H(18)Cl(2)N(2)O(5), was synthesized by the reaction of N'-(3,4-dichloro-benzyl-idene)-3,4,5-trimethoxy-benzo-hydrazide and acetic anhydride. The oxadiazole ring makes dihedral angles of 82.82 (7) and 9.92 (7)° with the 3,4-dichloro-benzene and the 3,4,5-trimethoxy-benzene ring planes, respectively. The crystal structure is stabilized by inter-molecular C-H⋯ O and C-H⋯ N...

In this work, the compound 2 named ethyl (1,1-dichloro-1a,5,5,7-tetramethyl-8-oxo-1a,2,3,4,5,5a,8,9-octahydro-1H-benzo[a]cyclopropa[b][7]annulen-6-yl)glycinate (C20H29Cl2NO3) was synthesized from ?,?-unsaturated sesquiterpene ketone 1 using azido-Schmidt reaction catalyzed by titanium tetrachloride (TiCl4). The structure of newly enaminone fully identified its HRMS, FT-IR, UV-Visible, NMR (1H &...

The reaction of 3,3-dichloro-2,2,4,4-tetramethylcyclobutanethione (1) with diazo compounds yielded spirocyclic 2,5-dihydro-1,3,4-thiadiazoles 3, which decomposed at ca. 45°C to give the corresponding thiocarbonyl ylide of type 4. In the absence of trapping agents, these thiocarbonyl ylides underwent a 1,3-dipolar electrocyclization to yield spirocyclic thiiranes 5. On the other hand, the thioca...