DiC14-amidine (N-t-butyl-N°-tetradecylaminopropionamidine) is a cationic lipid used as transfection agent in vitro [1] and as a vector for in vivo gene therapy applications. DiC14-amidine molecules assemble in a liposomal structure (transition temperature: 23C-critical micelle concentration: 10-7 M). Compared to other cationic lipids, diC14-amidine does not require a helper lipid. This property...

BACKGROUND Family studies have shown a strong heritability component for venous thromboembolism (VTE), but established genetic risk factors are present in only half of VTE patients. AIM To identify genetic risk factors in two large families with unexplained hereditary VTE. METHODS We performed whole exome sequencing in 10 affected relatives of two unrelated families with an unexplained tend...

Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-alpha, the product of the LTA gene, have been reported to be linked with the risk of myocardial infarction in Japanese. We employed nine polymorphisms from the BAT1-NFKBIL1-LTA region and one polymorphism from the LGALS2 gene, and investigated w...

INTRODUCTION A standard treatment for stage II colorectal cancer (CRC) is surgical resection without adjuvant chemotherapy. However, the recurrence rate of these patients is approximately 20%. To date, there are no robust biomarkers suitable for predicting recurrence in stage II CRC patients. In this study, microRNAs (miRNAs) extracted from CRC tissues were examined for a possible biomarker to ...

butunoate. glutamate, leucine, isoleucine, phenylalanine. threonine and valine; the organic acids glyoxylate, glycollate, oxalate, succinate, malonate, malate, citrate and glycerate; the fatty acids palmitate and stearate; the sterols campesterol, stigmasterol and sitosterol; the nitrogenous compounds urea, cytosine and uridine; and the poly-hydroxy compounds glycerol, a-glycerophosphatc. /I-gl...

rane (Suprane, Baxter Healthcare, Puerto Rico, USA) in the Dräger vaporizer (Dräger D-vapor, Dräger Medical GmbH, Lübeck, Germany) had turned yellow while filling the vaporizer (Fig. 1). We immediately changed the vaporizer. Yellow discoloration of desflurane occurs relatively infrequently and is not widely known; however, this was the second incident in our hospital. The yellowing of desfluran...

For an l-graph G, the Turán number ex(n,G) is the maximum number of edges in an n-vertex l-graph H containing no copy of G. The limit π(G) = limn→∞ ex (n,G)/ ( n l ) is known to exist [8]. The Ramsey-Turán density ρ(G) is defined similarly to π(G) except that we restrict to only those H with independence number o(n). A result of Erdős and Sós [3] states that π(G) = ρ(G) as long as for every edg...

Studies on the exploration of alternate fuels obtained from renewable sources of energy to supplement conventional fossil fuels are being carried out throughout the world. The edible and non edible oils are being tried to either supplement or to replace diesel as fuel in CI engines. India is the net importer of edible oils and, therefore, emphasis is being laid to explore the possibility of usi...