BACKGROUND Advances in pathophysiology and treatment of ankylosing spondylitis (AS) was recently demonstrated. However, the effect of anti-TNF in the newly described inflammatory pathways involved pathogenesis of this disease remains to be determined. The aim of our study was, therefore, to investigate long-term influence of anti-TNF drugs in IL-23/IL-17 axis of AS patients and their possible c...

Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, w...

Vol. 26 No. 1, 2014 139 Received December 7, 2012, Revised February 5, 2013, Accepted for publication March 31, 2013 Corresponding author: Hong Sang, Department of Dermatology, Jinling Hospital, Southern Medical University (Guangzhou) School of Medicine, 305 E Zhongshan Road, Nanjing 210002, Jiangsu Province, China. Tel: 86-25-8086-0092, Fax: 86-25-8481-5775, E-mail: [email protected] This is...

PURPOSE The interleukin-23 receptor (IL-23R) has been shown to be associated with ankylosing spondylitis (AS) in many different populations. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS Three single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, and rs17375018, were genotyped in 291 AS patient...