The expression and exact roles of miR-212-5p in CRC and the underlying molecular mechanism is still unclear. This study we aimed to investigate the expression and the role of miR-212-5p in colorectal cancer and further explore the underlying molecular mechanism. We first detected the expression level of miR-212-5p in colorectal cancer tissues and cells and we found that miR-212-5p was up-regula...

BACKGROUND microRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in carcinogenesis. In the present study, we investigated the effect of miR-212 on pancreatic ductal adenocarcinoma (PDAC) and its target protein. METHODS Quantitative real-time PCR(qRT-PCR) was performed to detect the expression of miR-212 in PDAC tissues and pancreatic cancer cell lines. miR-212 mimi...

BACKGROUND Despite radical surgical and chemotherapeutic treatment of ovarian cancer, the majority of patients develop recurrence and die due to progressive disease. Routine measurement of the tumor marker CA-125 is often used in the follow-up management. However, the role of preoperative CA-125 as a prognostic factor before secondary cytoreduction of relapsed ovarian cancer has not been determ...

MicroRNAs are important factors in the pathogenic processes of human types of cancers including nasopharyngeal carcinoma (NPC). In the present study, we confirmed that the microRNA-212 expression level was significantly decreased both in NPC tissues and NPC cell lines. Decreased expression of miR-212 was associated with advanced tumor-node-metastasis (TNM) stage and metastasis of NPC. Patients ...

OBJECTIVE MicroRNAs (miRs) function as either oncogenes or tumor suppressors in the progression of various human cancers, including cervical cancer. This study aimed to explore the role of miR-212 in cervical cancer and the mechanisms underlying this role. PATIENTS AND METHODS Quantitative real-time polymerase chain reaction (RT-PCR) and Western blot assays were used to determine the expressi...

BACKGROUND AND PURPOSE We assessed the contribution of antibody internalization in the efficacy and toxicity of intraperitoneal α-radioimmunotherapy (RIT) of small volume carcinomatosis using (212)Pb-labeled monoclonal antibodies (mAbs) that target HER2 (internalizing) or CEA (non-internalizing) receptors. MATERIALS AND METHODS Athymic nude mice bearing 2-3 mm intraperitoneal tumor xenografts...

Lung cancer is the leading cause of cancer-related mortality worldwide. microRNAs (miRNAs) are small post-transcriptional regulatory non-coding RNAs that function as oncogenes or tumor suppressors in human cancers. Emerging evidence reveals that deregulation of miRNAs contributes to the progression of human lung cancer, which is the leading cause of cancer-related deaths worldwide. In the prese...

Abstract Introduction Medical record keeping is a fundamental part of the GMC’s Good Practice [1,2]. Surgeons must ensure accurate, comprehensive, and legible records are maintained [3]. An operation note essential to continuity care between operating team other colleagues provides medicolegal patient’s [4]. Handover errors have been implicated in as many 80% sentinel events [5], highlighting i...

Wei Li,1 Li Huang,1,* Raj Ganesh S. Pala,2,3 Guang-Hong Lu,4,5 Feng Liu,6 James W. Evans,7,8 and Yong Han7,8,† 1Department of Physics, Southern University of Science and Technology, Shenzhen, Guangdong 518055, People’s Republic of China 2Department of Chemical Engineering, Indian Institute of Technology Kanpur, UP, 208016, India 3Material Science Programme, Indian Institute of Technology Kanpur...

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modif...