N -(2-Pyridylmethyl)iminodiacetic acid hemi-hydrate (H2pmda /0.5H2O) was prepared and characterized by X-ray crystallography (final R1 /0.042). The zwitterion H2pmda 9 is intra -stabilized by a trifurcated hydrogen bond. Intermolecular carboxyliccarboxylate hydrogen bonds and the parallel inter-ligand p,p-stacking (3.57(2) Å) between pyridyl rings from pairs of adjacent zwitterions generate 2D ...

1 INTRODUCTION. If inflectional morphology were perfectly straightforward, a listing of the inflected forms of a word for a given language would at the same time give us a list of the morphosyntactic values relevant for that language. For example in Yir-Yoront (1), a Pama-Nyungan language from the Cape York Peninsula, Australia, the distinct forms displayed by such words as 'foot' or 'leg' just...

The goal of this work is a systematic optimization of hydrophilic interaction liquid chromatography (HILIC) separation of acidic lipid classes (namely phosphatidic acids-PA, lysophosphatidic acids-LPA, phosphatidylserines-PS and lysophosphatidylserines-LPS) and other lipid classes under mass spectrometry (MS) compatible conditions. The main parameters included in this optimization are the type ...

A pyridine based 1,2-diamine containing only one stereogenic center has been identified for fast aldol reactions (16-48 h). Using 2-5 mol% of (R)- or (S)-PicAm-2, cyclohexanone (3.3 equiv) readily undergoes aldol reactions with o-, m-, and p-substituted aromatic aldehyde partners (limiting reagent), including the poor electrophile 4-methylbenzaldehyde (95-99% ee). Furthermore, functionalized cy...

Under favorable conditions, Caenorhabditis elegans larvae grow into reproductive adults after a series of molting cycles. When environmental conditions are harsh, they arrest as dauer larvae. Dafachronic acid (DA), a C. elegans steroid hormone, is required for reproductive development. Here, we report a mass spectrometry (MS) method for absolute quantitation of DA in C. elegans. The extraction ...

UNLABELLED Our understanding of estrogen (17β-estradiol, E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein-coupled estrogen receptor (GPER/GPR30) and the development of GPER-selective functional chemical probes. GPER is highly expressed in certain breast, endometrial, and ovarian cancers, establishing the importance ...

Pitjantjatjara is a dialect of the Western Desert Language (WDL) of central Australia (Douglas 1958). The Western Desert Language is a member of the south-west Pama-Nyungan group. Together with Warnman, it forms the Wati sub-group. It is spoken by 4000–5000 people, and covers the widest geographical area of any language in Australia, stretching from Woomera in central northern South Australia, ...

Penultimate stress in monomorphemic forms is invariant (1a-c). In suffixed forms (1d-f), by contrast, stress falls on the antepenultimate syllable. These deviations from penultimate stress serve a function: by retaining stress on the antepenult, stress of the suffixed stems matches stress of the stems in isolation. In this paper I show that an analysis of accentual faithfulness using base-deriv...