A new metal–organic complex (MOC), Mn(L)2·4H2O is successfully designed and synthesized by 2-(1,2,4-Triazol-1-yl)-4-picolinic acid ligand Mn(NO3)2·4H2O in the mixed solvent of methanol water. The was characterized single-crystal X-ray diffraction, element analysis, Powder diffraction(PXRD). binding constant between DNA 9.3 × 104, indicating that fish sperm can bind well. Viscosity experiments p...

An efficient method for the synthesis of the (S)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole ((S)-t-BuPyOx) ligand has been developed. Inconsistent yields and tedious purification in known routes to (S)-t-BuPyOx suggested the need for an efficient, dependable, and scalable synthetic route. Furthermore, a route suitable for the synthesis of PyOx derivatives is desirable. Herein, we descri...

Partial oxidation of 2-, 3and 4-picolines has received much attention because their oxidation products, picolinic acid, nicotinic acid and isonicotinic acid, respectively, are valuable intermediates of vitamins, food additives and pharmaceuticals1)~16). For example, 2-pyridinecarbaldehyde and picolinic acid are vitamins, feed stocks for synthesis of physiologically active substances, dyes and o...

O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods ...

The kynurenine pathway is a major route of L-tryptophan catabolism producing neuroactive metabolites implicated in neurodegeneration and immune tolerance. We characterized the kynurenine pathway in human neurons and the human SK-N-SH neuroblastoma cell line and found that the kynurenine pathway enzymes were variably expressed. Picolinic carboxylase was expressed only in primary and some adult n...

A novel 12-molybdophosphoric acid (HPM)-based complex (H2PI)2(H3O)[PMo12O40] [Mo2O5(H2O)2(PI)2]·11H2O (PI-HPM) was prepared by modification with picolinic acid (HPI) and characterized by the methods of Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG), X-ray powder and single crystal diffraction. The complex retained the classical Keggin structure of bulk HPM, there were som...

In order to clarify the mechanism by polyphenols of protective effects against oxidative damage or by quinolinic acid of its neurotoxic and inflammatory actions, effects of polyphenols or quinolinic acid on the radical formation were examined. The ESR measurements showed that some polyphenols such as caffeic acid, catechol, gallic acid, D-(+)-catechin, L-dopa, chlorogenic acid and L-noradrenali...

Studies were undertaken to determine the effect of chemical inhibitors on the sporulation of thermophilic anaerobes of which Clostridium thermosaccharolyticum is a representative organism. Since fluoroacetic acid (R. S. Hanson, Ph.D. Thesis, Univ. of Illinois, Urbana, 1962), diethyl malonate (6), and a-picolinic acid (pyridine-6-carboxylic acid; reference 3) have been found to inhibit the sporu...