LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...

LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...

Phenylboronic acid esters are formed by the three common 2-deoxy aldoses: 2-deoxy-d-erythro-pentose ('2-deoxy-d-ribose'), 2-deoxy-d-lyxo-hexose ('2-deoxy-d-galactose'), and 2-deoxy-d-arabino-hexose ('2-deoxy-d-glucose'). The major species that was formed from equimolar quantities of boronic acid and the aldose, was the 3,4-monoester of the pentopyranose in a skew-boat conformation, and the 4,6-...

The culture for 7 days in medium with 5.5 mM glucose and 1 mM 2-deoxy-D-glucose enhanced the glucose sensitivity of neonatal rat B cells, and even stimulated their growth in vitro. Also, 2-deoxy-D-glucose supplementation maintained insulin release evoked by leucine and 2-ketoisocaproate from B cells at day 7 at levels several times higher than at day 1. The effect of leucine was greatly augment...

The effects of α- and β-2-deoxy-d-glucose tetraacetate (1.7 and 8.5 mM) on insulin, somatostatin, and glucagon secretion from isolated rat pancreases perfused in the presence of 8.3 mM d-glucose were compared with those of unesterified 2-deoxy-d-glucose tested at the same two concentrations. The unesterified glucose analog caused, in a concentration-related manner, inhibition of glucose-induced...