MnCo2O4 (MnO-Co2O3) nanocomposite as a binary oxide has been successfully prepared by precipitation method using cobalt nitrate and manganese nitrate as the precursors and then characterized by scanning electron microscopy-energy dispersive micro-analysis (SEM-EDX) and X-ray diffraction (XRD) techniques. In this work, we report the hydrolysis kinetics reactions of semi mustard (chloroethyl ethy...

The photooxidation of a mustard-gas simulant, 2-chloroethyl ethyl sulfide (CEES), is studied using a porphyrin-based metal-organic framework (MOF) catalyst. At room temperature and neutral pH value, singlet oxygen is generated by PCN-222/MOF-545 using an inexpensive and commercially available light-emitting diode. The singlet oxygen produced by PCN-222/MOF-545 selectively oxidizes CEES to the c...

OBJECTIVE Sulfur mustard is a well-known blistering chemical warfare agent that has been investigated for its toxicological mechanisms and an efficacious antidote. Since sulfur mustard injury involves dermal:epidermal separation, proteolytic enzymes were suspected to be involved for this separation and eventual blister development. Therefore, protease inhibitors could be of therapeutic utility ...

The gas chromatography method with direct injection for quantitative determination of residual nonvolatile solvents such as 2-(2-chloroethoxy)ethanol (CEE) and N-methyl-2-pyrrolidinone (NMP) in quetiapine--the pharmaceutical active substance has been validated. Validation was performed according to the requirement of ICH validation guidelines Q2A and Q2B. Specificity, precision, accuracy, linea...

N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) are antimicrotubule agents interacting covalently with β-tubulin near the colchicine-binding site (C-BS). Glutamyl 198 residue in β-tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, has been shown to covalently react with 1-(2-chloroethyl)-3-(4-iodophenyl)urea (ICEU). By use of mass spectrometr...

N-Phenyl-N -(2-chloroethyl)ureas (CEUs) are antimicrotubule agents interacting covalently with -tubulin near the colchicine-binding site (C-BS). Glutamyl 198 residue in -tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, has been shown to covalently react with 1-(2-chloroethyl)-3-(4iodophenyl)urea (ICEU). By use of mass spectrometry, ...

The decontamination and remediation of sulfur mustard chemical warfare agents remains an ongoing challenge. Herein, we report the use of "off-the-shelf" metal salts alongside commercially available peroxides to catalyze the degradation of the simulant 2-chloroethyl ethyl sulfide (CEES) in solution and encapsulated within a supramolecular gel.

Ligand Hsal-his (I) derived from salicylaldehyde and histamine has been covalently bound to chloromethylated polystyrene cross-linked with 5% divinylbenzene. Upon treatment with [VO(acac)(2)] in DMF, the polystyrene-bound ligand (abbreviated as PS-Hsal-his, II) gave the stable polystyrene-bound oxidovanadium(iv) complex PS-[V(IV)O(sal-his)(acac)] , which upon oxidation yielded the dioxidovanadi...