نتایج جستجو برای: 2 benzisothiazol 3 one derivatives

تعداد نتایج: 4779857  

Journal: :Biomolecules 2021

Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding recognized as the main underlying pathogenic mechanism PKU. Therefore, use stabilizers protein structure and/or an attractive therapeutic strategy for this condition. Here, we report that 3-hydroxyqu...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2018
R Scott Obach Jian Lin Emi Kimoto Sridhar Duvvuri Timothy Nicholas Eugene P Kadar Larry M Tremaine Aarti Sawant-Basak

(R)-4-((4-(((4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol (TBPT), a serotonin-4 receptor partial agonist, is metabolized to two metabolites: an N-dealkylation product [(R)-3-(piperidin-4-ylmethoxy)-4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazole (M1)] and a cyclized oxazolidine structure [7-(((4-(((R)-tetrahydrofuran-3-yl)oxy)benzo[...

Natural mesolite type zeolite was collected, modified by sulfuric acid treatment and characterized by using Powder-X ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR).Temperature programmed ammonia desorption (NH3-TPD), Brunauer-Emmer-Teller (BET) surface area analysis.  Modified dealuminat...

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