BACKGROUND Takotsubo cardiomyopathy (TCM) is characterized by regional left ventricular dysfunction that cannot be explained by an occlusive lesion in a coronary artery. Catecholamines are implicated in the pathogenesis of TCM but the mechanisms involved are unknown. Because the endogenous and the most commonly used exogenous catecholamines have well defined adrenoceptor subtype affinities, inf...

BACKGROUND AND PURPOSE CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the β1 -adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity β1 -adrenoceptor site or conformation. β-blocker affinities for this 'CGP 12177' site of the human β1 -adrenoceptor have thus far only been ch...

These experiments investigated the role of the alpha(2)-adrenoceptors of the basolateral nucleus of the amygdala (BLA) in modulating the retention of inhibitory avoidance (IA). In Experiment 1, male Sprague Dawley rats implanted with bilateral cannulae in the BLA received microinfusions of a selective alpha(2)-adrenoceptor antagonist idazoxan 20 min either before or immediately after training. ...

Catecholamine-induced lipolysis in isolated human adipocytes during the first year of life was investigated. During this period fat cell size increased markedly. Basal and catecholamine-induced glycerol release were positively correlated with age when lipolysis was expressed per cell. However, when lipolysis was expressed per unit of cell surface area (micrometer squared), this correlation was ...

The objective of the present study was to evaluate the effects of a selective beta(3)-adrenoceptor agonist, (R, R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1, 3-benzodioxole-2,2-dicarboxylate (CL 316243), on the acutely obstructed ureter in anesthetized dogs. After a complete ureteral obstruction produced by the inflation of a balloon catheter placed within the left lower ureter,...

These experiments investigated the role of the 2-adrenoceptors of the basolateral nucleus of the amygdala (BLA) in modulating the retention of inhibitory avoidance (IA). In Experiment 1, male Sprague Dawley rats implanted with bilateral cannulae in the BLA received microinfusions of a selective 2-adrenoceptor antagonist idazoxan 20 min either before or immediately after training. Retention was ...

The nomenclature of the Adrenoceptors has been agreed by NC-IUPHAR Subcommittee on [64, 194]. Adrenoceptors, α1 three α1-adrenoceptor subtypes α1A, α1B and α1D are activated endogenous agonists (-)-adrenaline (-)-noradrenaline. -(-)phenylephrine, methoxamine cirazoline prazosin doxazosin antagonists considered selective for α1- relative to α2-adrenoceptors. [3H]prazosin [125I]HEAT (BE2254) rela...

1. The subtype and anatomical localization of beta-adrenoceptors mediating facilitation of stimulus-induced overflow of noradrenaline ('prejunctional beta-adrenoceptors') are not conclusively known to date. The present study was undertaken to characterize these receptors by use of pharmacological methods as well as to define their localization (prejunctional or postjunctional) with radio-ligand...

We investigated the a,-adrenoceptor subtypes of rabbit saphenous vein which has a mixed functional population of α1 and α2 -adrenoceptors. Lateral saphenous veins were obtained from male rabbits weighing 3.20-4 kg, which were killed by overdose with pentobarbitone sodium (i.v. injection). They were easily dissected out and placed in cold, oxygenated modified Krebs-Henselite solution (Krebs)...