PURPOSE To investigate the molecular mechanism underlying intrinsic resistance to ABT-199. EXPERIMENTAL DESIGN Western blots and real-time RT-PCR were used to determine levels of Mcl-1 after ABT-199 treatment alone or in combination with cytarabine or daunorubicin. Immunoprecipitation of Bim and Mcl-1 were used to determine the effect of ABT-199 treatment on their interactions with Bcl-2 fami...

There are multiple reasons why anisotropic basis functions may be needed or be more appropriate. The most obvious is that if the basis function is to be defined on Rn × T then there is no natural norm on this space that would reflect the unique properties of time. A second reason is that function being interpolated or approximated may incorporate a directional dependence. Thirdly, differentiabi...

The implementation of implicit Runge{Kutta methods requires the solution of large systems of non-linear equations. Normally these equations are solved by a modiied Newton process, which can be very expensive for problems of high dimension. The recently proposed triangularly implicit iteration methods for ODE-IVP solvers 5] substitute the Runge{Kutta matrix A in the Newton process for a triangul...

Running title: Combination of ABT-199 and ibrutinib for CLL