The mechanisms responsible for the development and course of rheumatic diseases are not yet fully explained. Molecular imaging is one of the tools used to investigate them, with nuclear medicine being its prominent part. Unlike computed tomography (CT), ultrasonography (USG), or magnetic resonance imaging (MRI), which reveal only structural disorders, radioisotope imaging enables us to present ...

The ability to demonstrate tumour foci that are undetected by conventional imaging has resulted in the emergence of positron emission tomography (PET) as a valuable clinical tool in oncology. This article describes the technique and indications for fluorine-18 labelled fluorodeoxyglucose (18FDG)-PET in lung cancer, demonstrating the high accuracy and cost-effectiveness of 18FDG-PET in the chara...

introduction: a noninvasive method of detecting exposure of phosphatidylserine (ps) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. the most studied imaging agent for apoptosis is annexin v so far. because of limitations of annexin v other agents have been introduced such as small peptides and molecu...

To the Editor: Bartonella spp. cause 2% of cases of blood culture– negative endocarditis (1). Early diagnosis of Bartonella spp. infectious endocarditis, is challenging, especially for patients with preexisting valvular heart disease. A diagnosis for these patients requires bacterial culture, serologic testing, or molecular detection in serum or tissue (2). The sensitivity and specificity of Du...

In animal models of pulmonary inflammation, neutrophils exhibit a dramatic influx of glucose in periods of high metabolic activity. This information was utilized to develop a technique, involving positron emission tomography (PET) of 2-[18F]-fluoro-2-deoxy-D-glucose (18FDG), which measures neutrophil activity in situ. This technique was applied in a comparative study of neutrophil function in p...

Standardized uptake value (SUV), which is an indicator of the degree of glucose uptake in 18Ffluorodeoxy-glucose positron emission tomography (18FDG-PET), can be applied as a prognostic factor in various malignant tumors. We investigated the prognostic impact of early changes in 18FDG-PET uptake in patients with locally advanced breast cancer who received neoadjuvant chemotherapy (NAC). Methods...

As freon is limited in its use as a generator for aerosol inhalation, powder particles are used as an alternative for inhalation therapy. The pulmonary deposition and clearance of inhaled powder particles was studied by positron emission tomography (PET) in ten patients with chronic obstructive pulmonary disease (COPD) and in five normal controls. The powder, 5 microm in mean diameter, was wate...

BACKGROUND AND PURPOSE We investigated whether uptake of (18)fluoro-2-deoxy-d-glucose (18FDG) positron emission tomography-computed tomography (PET-CT) correlated to clinical symptoms and presence of microembolic signals (MES) detected by transcranial Doppler in patients with carotid stenosis. METHODS 18FDG-PET-CT and MES detection was performed in consecutive patients with 50% to 99% symptom...