miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related function in vivo remained unclear. Here, we report that the miR-184 knockout mouse model displayed increased p63 expression in line with epidermal hyperplasia,...

The crystal structure of a putative dipeptidase (Phdpd) from Pyrococcus horikoshii OT3 was solved using X-ray data at 2.4 A resolution. The protein is folded into two distinct entities. The N-terminal domain consists of the general topology of the alpha/beta fold, and the C-terminal domain consists of five long mixed strands, four helices, and two 3(10) helices. The structure of Phdpd is quite ...

m-miR-184 (mutant miR-184, r.57c > u) appears in familial hereditary ocular diseases, including keratoconus, cataracts, EDICT (endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning) syndrome, severe keratoconus, and non-ectatic corneal thinning. The biological function of m-miR-184 in these ocular diseases remains unclear. With the emergence of high-throughput sequen...

background: given the importance of vegetables in the food pyramid, their safety is very important from view point of public health. vegetable contamination by heavy metals can lead to bioaccumulation of these toxic and disease-causing elements in the body of consumers. therefore, in this study, the concentration of some heavy metals, including lead (pb), cadmium (cd), zinc (zn) and copper (cu)...

Corresponding Author Tel: +385 51 651 150 Fax: +385 51 675 699 E-mail: [email protected] BACKGROUND: Peptidoglycan monomer (PGM), which was originally prepared by biosynthesis from culture fluids of penicillin-treated Brevibacterium divaricatum, is an immunostimulator, the activities of which might be improved by addition of zinc (Zn) to the basic molecule. Methods: To test the possible cytotoxic...

Voting (or rank aggregation) is a general method for aggregating the preferences of multiple agents. One voting rule of particular interest is the Kemeny rule, which minimizes the number of cases where the final ranking disagrees with a vote on the order of two alternatives. Unfortunately, Kemeny rankings are NP-hard to compute. Recent work on computing Kemeny rankings has focused on producing ...

In this paper, a family of multi-value cellular automaton (CA) associated with traffic flow is presented. The family is obtained by extending the rule–184 CA, which is an ultradiscrete analogue to the Burgers equation. CA models in the family show both metastable states and stop-and-go waves, which are often observed in real traffic flow. Metastable states in the models exist not only on a prom...

We consider a model in which voters over time receive more information about their preferences concerning an irreversible social decision. Voters can either implement the project in the first period, or they can postpone the decision to the second period. We analyze the effects of different majority rules. Individual first period voting behavior may become “less conservative” under supermajorit...