inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, uv radiation, stress and etc. persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from t cells. these molecules (e.g. il-6, tnf-α, il-1β and il-17) are mostly pleiotropic cytokines involved i...

Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...

Lung cancer is responsible for more cancer-related death worldwide. Most lung patients have non-small cell cancers (NSCLC), with a low survival rate. Therefore, it necessary to study new and effective targeted therapies. Discoidin domain receptor 1 (DDR1) tyrosine kinase that can be promoted by collagen type I, dysregulation of DDR1 signaling involved in several phases tumorigenesis. Tumor grow...

Heat shock protein 90 (Hsp90) is a molecular chaperone involved in maintaining the correct conformation and stability of its client proteins. This study investigated the effects of Hsp90 inhibitors on client protein expression and key cellular functions required for tumor angiogenesis. The benzoquinone ansamycin Hsp90 inhibitors geldanamycin and/or its derivatives 17-allylamino-17-demethoxygeld...

Introduction As a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. In this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. Materials and Methods In the avascular growth model, tumor is considered as a single mass, wh...

statement of the problem: odontogenic keratocyst (okc) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion. purpose: the aim of the present study was to determine the mean vascular densities (mvd) of ...