نتایج جستجو برای: 17β hydroxysteroid dehydrogenase type1
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Heterodera glycines Hg-hsd-1 and Hg-hsd-2 are two homologues of let-767, a short-chain dehydrogenase gene from the free-living nematode Caenorhabditis elegans. Both genes share similarity to 17β-hydroxysteroid dehydrogenases (17β-HSDs), enzymes known to be involved in the production of steroid hormones in mammals. Hg-hsd-1 and Hg-hsd-2 encode distinct protein sequences that share 51% amino acid...
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the active steroid hormones estradiol, testosterone, and 5α-dihydrotestosterone into their weakly active forms estrone, Δ4-androstene-3,17-dione, and 5α-androstane-3,17-dione, respectively, thereby regulating cell- and tissue-specific steroid action. As reduced levels of active steroids are associated with compromised bone health and o...
17βHSD enzymes catalyze the stereospecific oxidation/reduction at carbon 17β of androgens and estrogens, and are important players in intracrine sex hormone synthesis. The biological relevance of 17βHSD14, first named retSDR3, is largely unknown. We generated and validated an antibody targeting the 17βHSD14 antigen and used this for immunohistochemical evaluation of expression patterns in 33 he...
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