نتایج جستجو برای: 165

تعداد نتایج: 12961  

Journal: :Blood 2004
Simon Rollin Caroline Lemieux Ricardo Maliba Judith Favier Louis R Villeneuve Bruce G Allen Shay Soker Nicolas G Bazan Yahye Merhi Martin G Sirois

The acute increase in vascular permeability produced by vascular endothelial growth factor (VEGF-A(165)) requires activation of endothelial Flk-1 receptors (VEGFR-2) and stimulation of platelet-activating factor (PAF) synthesis. Like PAF, VEGF-A(165) promotes translocation of P-selectin to the endothelial cell (EC) surface. However, the mechanisms involved remain unknown. By treating human umbi...

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Journal: :Plant Signaling & Behavior 2007

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Journal: :The FASEB Journal 2008

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Journal: :The Journal of biological chemistry 2002
Gakuji Hashimoto Isao Inoki Yutaka Fujii Takanori Aoki Eiji Ikeda Yasunori Okada

Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role in angiogenesis under various pathophysiological conditions. We have recently demonstrated that VEGF(165), one of the VEGF isoforms, binds connective tissue growth factor (CTGF) and that its angiogenic activity is inhibited in the VEGF(165).CTGF complex form (Inoki, I., Shiomi, T., Hashimoto, G., Enomot...

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Journal: :Journal of neurotrauma 2010
Olivera Nesic Laura M Sundberg Juan J Herrera Venkata U L Mokkapati Julieann Lee Ponnada A Narayana

Vascular endothelial growth factor (VEGF)-A mRNA was previously identified as one of the significantly upregulated transcripts in spinal cord injured tissue from adult rats that developed allodynia. To characterize the role of VEGF-A in the development of pain in spinal cord injury (SCI), we analyzed mechanical allodynia in SCI rats that were treated with either vehicle, VEGF-A isoform 165 (VEG...

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Journal: :The Journal of biological chemistry 2001
G B Whitaker B J Limberg J S Rosenbaum

The two most abundant secreted isoforms of vascular endothelial growth factor A (VEGF(165) and VEGF(121)) are formed as a result of differential splicing of the VEGF-A gene. VEGF(165) and VEGF(121) share similar affinities at the isolated VEGF receptor (VEGFR)-2 but have been previously demonstrated to have differential ability to activate VEGFR-2-mediated effects on endothelial cells. Herein w...

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Journal: :PLoS ONE 2006
Pia Leppänen Ivana Kholová Anssi J. Mähönen Kari Airenne Suvi Koota Hannu Mansukoski Johanna Närväinen Maria Wirzenius Leena Alhonen Juhani Jänne Kari Alitalo Seppo Ylä-Herttuala

We have generated a transgenic mouse where hVEGF-A(165) expression has been silenced with loxP-STOP fragment, and we used this model to study the effects of hVEGF-A(165) over-expression in mice after systemic adenovirus mediated Cre-gene transfer. Unlike previous conventional transgenic models, this model leads to the expression of hVEGF-A(165) in only a low number of cells in the target tissue...

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Journal: :Journal of Applied Clinical Medical Physics 2014

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Journal: :American journal of physiology. Heart and circulatory physiology 2004
Homa Ashrafpour Ning Huang Peter C Neligan Christopher R Forrest Patrick D Addison Michael A Moses Ronald H Levine Cho Y Pang

Various laboratories have reported that local subcutaneous or subdermal injection of VEGF(165) at the time of surgery effectively attenuated ischemic necrosis in rat skin flaps, but the mechanism was not studied and enhanced angiogenesis was implicated. In the present study, we used the clinically relevant isolated perfused 6 x 16-cm pig buttock skin flap model to 1) test our hypothesis that VE...

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Journal: :Astronomische Nachrichten 1876

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