We recently demonstrated that the orphan nuclear receptor testicular receptor 4 (TR4) is a potent regulator of corticotroph tumor growth and hormone secretion. The Ras/Raf/MEK/ERK pathway is commonly overactivated in human tumors and we have demonstrated that corticotroph tumor TR4 is activated by ERK1/2-mediated phosphorylation. We evaluated effects of MEK-162, a selective, non-ATP-competitive...

Department of Applied Chinese Languages and Literature, National Taiwan Normal University, 162, Sec. 1, Ho-Ping E. Rd., Taipei, Taiwan Department of Educational Psychology and Counseling, National Taiwan Normal University, 162, Sec. 1, Ho-Ping E. Rd., Taipei, Taiwan Graduate Institute of Information and Computer Education, National Taiwan Normal University, 162, Sec. 1, Ho-Ping E. Rd., Taipei, ...

Subtype H1N1 influenza A virus (IAV) that caused a pandemic in 2009, called A(H1N1)pdm09, has been circulating as seasonal IAV among humans, escaping from herd immunity through amino acid substitutions hemagglutinin (HA). Additionally, position 162 of HA A(H1N1)pdm09 evolved to be N-linked glycosylated by 2017. Here the effect glycosylation at was examined comparing ratio nonsynonymous diversit...