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This perspective on the report by Fakhry and colleagues in this issue of the journal (beginning on page 1378) examines the diagnostic accuracy of a "Pap-test equivalent" for screening for human papillomavirus (HPV)-associated cancers in the tonsils. HPV infection is strongly associated with cancer development in the oropharynx (tonsils and base of tongue) and cervix; the data discussed here und...

The Bremen-Cog was dated by dendrochronology in the 1960s when discipline its infancy. felling date of winter 1378/79 Weser Uplands established and confirmed 2007. In 2016 a new comprehensive analysis ship made possible. All analysed samples are from trees likely felled last quarter 14th century direct hinterlands Bremen. Furthermore, an attempt at tree morphology reconstruction detailed invest...

Abstract This article focuses on the seven monumental Qur’āns made during reign of Sultan al-Ashraf Shaʿbān II (r. 1363–1378), considered to be masterpieces Mamluk arts book. These are MSS Cairo, Dār al-Kutub al-Miṣriyya Raṣīd 6, 7, 8, 9, 10, 15, and 54. The aim this study is deepen our knowledge manufacturing system context production these manuscripts through examination paper formats, writin...

The neuromatrix theory of pain proposes that pain is a multidimensional experience produced by characteristic “neurosignature” patterns of nerve impulses generated by a widely distributed neural network—the “body-self neuromatrix”—in the brain. These neurosignature patterns may be triggered by sensory inputs, but they may also be generated independently of them. Acute pains evoked by brief noxi...