Bone morphogenetic protein (BMP) signaling plays many roles in skull morphogenesis. We have previously reported that enhanced BMP signaling through the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis during postnatal development. Additionally, we observed that 55% of Bmpr1a mutant mice show neonatal lethality characterized by a distended gastrointestinal trac...

. Establishment in 1973 as an organ of the Nordiska Samarbetskommitten för Arktisk Medicinsk Forskning (NoSAMF), reporting to and financed by the Nordic Council of Ministers (NCM). . The dissolution of NoSAMF in 1996 and the transfer of the journal to joint ownership by the Nordic Society for Arctic Medicine (NSAM) and the International Union of Circumpolar Health (IUCH). Editorial and administ...

Starting with the January 2012 issue, a new team takes the reins of Diabetes. A question that many people have asked is whether the new leadership will change Diabetes. My answer would be, of course, that change is necessary to respond to new challenges arising from the continual transformation of technology and science. Such changes have been continuously transforming Diabetes since its incept...

We study the problem of guarding orthogonal art galleries with horizontal mobile guards (alternatively, vertical) and point guards, using “rectangular vision”. We prove a sharp bound on the minimum number of point guards required to cover the gallery in terms of the minimum number of vertical mobile guards and the minimum number of horizontal mobile guards required to cover the gallery. Further...

This paper focuses on a variation of the Art Gallery problem that considers open edge guards and open mobile guards. A mobile guard can be placed on edges and diagonals of a polygon, and the “open” prefix means that the endpoints of such edge or diagonal are not taken into account for visibility purposes. This paper studies the number of guards that are sufficient and sometimes necessary to gua...

One of the earliest and most well known problems in computational geometry is the socalled art gallery problem. The goal is to compute the minimum possible number guards placed on the vertices of a simple polygon in such a way that they cover the interior of the polygon. In this paper we consider the problem of guarding an art gallery which is modeled as a polygon with curvilinear walls. Our ma...