Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in the metabolism of several important therapeutic agents, drugs of abuse, and endogenous compounds. However, no studies have described the role of human CES1 in the activation of two commonly prescribed angiotensinconverting enzyme inhibitors: enalapril and ramipril. Here, we studied recombinant human CES1a...

References pa.2009.0449.full.html#ref-list-1 http://rspa.royalsocietypublishing.org/content/early/2009/12/18/rs This article cites 13 articles, 2 of which can be accessed free P<P journal. Published online 23 December 2009 in advance of the print Subject collections (133 articles) applied mathematics (50 articles) climatology (31 articles) statistical physics Articles on similar topics ca...

The sensitivity of (129)Xe chemical shifts to weak nonspecific xenon-protein interactions has suggested the use of xenon to probe biomolecular structure and interactions. The realization of this potential necessitates a further understanding of how different macromolecular properties influence the (129)Xe chemical shift in aqueous solution. Toward this goal, we have acquired (129)Xe NMR spectra...

Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and the CBF values; either on the affected hemisphere or on the contralateral one....

The 14 November 2000, Ms8.1 Kokoxili earthquake is of huge influence in the world, which ruptured more than 400 km of the western end of the left-lateral Kunlun fault. The Kunlun fault is active and also after the heavy earthquake, it will definitely undergo an adjusting and balancing process. SAR Intereferometry (INSAR) is an effective measure for crustal deformation measurement even for minor...

Neuropsychological research frequently uses non-clinical undergraduate participants to evaluate neuropsychological tests. However, a recent study by An and colleagues (2012, Archives of Clinical Neuropsychology, 27, 849-857) called into question that the extent to which the interpretation of these participants' performance on neuropsychological tests is valid. This study found that in a sample ...

Safety and security are key aspects for the success of tourism in every destination. Rather than objective risks, it is rather the tourist's individual and subjective perception of these risks that mostly infl uence destination choice and in the long run tourism fl ows from one country to another. Th e concept of risk perception has been highly studied in tourism, however the literature remains...

Stakeholders' perceptions towards tourism development within destinations have been emphasized by researchers and practitioners. However, literature has only focused local residents' role in tourism development, leaving a gap in knowledge on stakeholders' engagement in tourism development process. Th is study investigates stakeholders' perceptions, attitudes and involvement in tourism developme...