1. Kara O, Arik G, Sumer F et al. Only frailty? What about other factors affecting cognition? J Am Geriatr Soc 2015;63:1281–1282. 2. Robertson DA, Savva GM, Coen RF et al. Cognitive function in the prefrailty and frailty syndrome. J Am Geriatr Soc 2014;62:2118–2124. 3. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56A...

Gray, G. M. & Macfarlane, M. G. (1961). Biochem. J. 81, 480. Hanes, C. S. & Isherwood, F. A. (1949). Nature, Lond., 164, 1107. Hirsch, J. & Ahrens, E. H. (1958). J. biol. Chem. 233, 311. Igarashi, H., Zama, K. & Katada, M. (1958). Nature, Lond., 181, 1282. Kittredge, J. S., Roberts, E. & Simonsen, D. G. (1962). Biochemi8try, 1, 624. Lea, C. H. & Rhodes, D. N. (1953). Biochem. J. 54, 467. Marine...

Tamoxifen is an anticancer drug that induces oxidative stress and apoptosis via mitochondria-dependent and nitric oxide (NO)–dependent pathways. The present report shows that tamoxifen increases intramitochondrial ionized Ca concentration and stimulates mitochondrial NO synthase (mtNOS) activity in the mitochondria from rat liver and human breast cancer MCF-7 cells. By stimulating mtNOS, tamoxi...

2010;56;1267-1282; originally published online Sep 21, 2010; J. Am. Coll. Cardiol. Park, and Jeffrey J. Popma Seung-Jung Day, Roger Hall, Martin B. Leon, Ziyad M. Hijazi, Francis Marchlinski, Gregory J. Dehmer, John S. Douglas, Jr, Alexander Abizaid, Jessica W. Berg, John Standards for the Future Demonstrations at Cardiology Meetings: Assessments of the Past and SCAI/ACCF/HRS/ESC/SOLACI/APSIC S...

We studied a dynamical model for the motion of the large scales of proteins in water. The model was obtained by projecting the (averaged) Newton equations onto some set of harmonic modes. We compared the statistics of the so-obtained trajectories with those obtained by standard techniques, and concluded that our dynamical model is able to fairly reproduce the average properties of the large-sca...

In a time of increased patient loads and emergency department (ED) exit block, the need for strategies to manage patient flow in the ED has become increasingly important. In March 2002 we contacted all 1282 members of the Canadian Association of Emergency Physicians and asked them to delineate strategies for enhancing ED patient flow and ED productivity without increasing stress levels, reducin...

We resolve an open problem raised by Ravikumar and Ibarra [SIAM J. Comput., 18 (1989), pp. 1263–1282] on the succinctness of representations relating to the types of ambiguity of finite automata. We show that there exists a family of nondeterministic finite automata {An} over a two-letter alphabet such that, for any positive integer n, An is exponentially ambiguous and has n states, whereas the...

Given a topological group G that can be embedded as subgroup into some vector space (over the field of reals) we say has invariant linear span if all spans under arbitrary embeddings spaces are isomorphic spaces. For an set A let $${{\mathbb {Z}}}^{(A)}$$ direct sum |A|-many copies discrete integers endowed with Tychonoff product topology. We show span. This answers question from paper Dikranja...