نتایج جستجو برای: 126
تعداد نتایج: 17783 فیلتر نتایج به سال:
MicroRNA-126 (miR-126) suppresses the migration, proliferation and invasion of colon cancer cells. However, the underlying mechanisms of miR-126 in colon cancer have not been fully elucidated. In this study, in vivo experiments revealed that miR-126 inhibits colon cancer growth and metastasis. Furthermore, miR-126 was down-regulated in human colon cancer tissue, and its expression was inversely...
زمینه و هدف: بتا دفنسین126 انسانی یک گلیکوپروتئین کوچک کاتیونی (12کیلو دالتون) بسیار غنی از سیستئین است. ژن این پروتئین در انسان بر روی انتهای تلومری بازوی کوتاه کروموزوم 20 قرار دارد. بیان بالایی از این پروتئین در اپیدیدیم گزارش شده است. این پلی پپتید سطح سلول های اسپرم را در حین عبور از اپیدیدیم پوشش می دهد. از آنجا که بتا دفنسین 126 در بلوغ و ظرفیت پذیری اسپرم موثر است، می تواند نقش مهمی در ...
The abnormal expression of several microRNAs has a causal role in tumorigenesis with either antineoplastic or oncogenic functions. Here we demonstrated that miR-126 and miR-126* play a tumor suppressor role in human melanoma through the direct or indirect repression of several key oncogenic molecules. The expression levels of miR-126&126* were elevated in normal melanocytes and primary melanoma...
BACKGROUND It is controversial whether microRNA-126 is a tumor suppressive or oncogenic miRNA. More experiments are needed to determine whether microRNA-126 is associated with non-small cell lung cancer risk and prognosis. METHODS Over-expression of microRNA-126 was performed to evaluate the cell invasion and tumor growth in non-small cell lung cancer (NSCLC) cell lines and nude mouse xenogra...
BACKGROUND & AIMS MicroRNAs (miRNAs) have been shown to play essential roles in HSCs activation which contributes to hepatic fibrosis. Our previous miRNA microarray results suggested that miR-126 might be decreased during HSCs activation as other studies. The aim of this study is to investigate the role of miR-126 during HSCs activation. METHODS In this study, the expression of miR-126 during...
Xianhui Qin ([email protected]) Jianping Li ([email protected]) Yimin Cui ([email protected]) Zeyuan Liu ([email protected]) Zhigang Zhao ([email protected]) Junbo Ge ([email protected]) Deming Guan ([email protected]) Jian Hu ([email protected]) Yanni Wang ([email protected]) Fumin Zhang ([email protected]) Xin Xu ([email protected]) Xiaobin Wang ([email protected]) Xiping...
MicroRNAs (miRNAs) are involved in cancer development and progression. Renal cell carcinoma (RCC) frequently undergoes metastasis and has a high mortality rate. The current study measured miRNA‑126 (miR‑126) expression levels in 128 pairs of clear cell RCC and adjacent normal kidney tissue samples by reverse transcription‑quantitative polymerase chain reaction, and analyzed the association betw...
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