Vitamin D has received more attention in recent years as a result of the resurgence vitamin deficiency and rickets global health issue, well compelling evidence laboratory indicating that 1,25-dihydroxy D3 [1,25(OH)2D3], hormonally active form D, generates several extraskeletal biological responses such inhibition breast, colon, prostate cancer cell progression; effects on cardiovascular system...

24-Keto-1,25-dihydroxyvitamin D3 has been identified as an intestinal metabolite of 1,25-dihydroxyvitamin D3 by ultraviolet absorbance, mass spectroscopy, and chemical reactivity. The metabolite was produced from 1,25-dihydroxyvitamin D3 and 1,24R,25-trihydroxyvitamin D3 in rat intestinal mucosa homogenates. 24-Keto-1,25-dihydroxyvitamin D3 is present in vivo in the plasma and small intestinal ...

Proposal Strong epidemiologic evidence supports a role for vitamin D insufficiency as a risk factor for multiple sclerosis (MS), shown by increasing disease prevalence with increasing latitude, and inverse correlation with duration and intensity of ultraviolet B (UVB) sunlight exposure and vitamin D serum concentration. 1 Moreover, MS risk seems to decrease with migration from higher latitudes ...

Three experiments were conducted to determine whether feeding 25-hydroxyvitamin D3 (25-OH D3) or 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3) improves the tenderness of longissimus dorsi (LD), semimembranosus (SM), and infraspinatus (IF) muscles similar to supplemental vitamin D3 without leaving residual vitamin D3 and its metabolites in muscle. In the first two experiments, 24 crossbred steers wer...

Etiologycaly, possible causes of subfertility or infertility in men are poorly defined, but one important category may be elevated level of antisperm antibodies (ASA) caused by infective and/or auto-immune diseases of male reproductive system. In this study, blood sera from 45 infertile men of different age with ASA positive ELISA test were examined for the serum level of ASA before and after t...

Phosphate accumulation by muscle in vitro and the effects of vitamin D3 metabolites thereupon were studied in cultures of chick embryo skeletal muscle myoblasts and intact chick soleus muscles. A significant proportion of phosphate accumulation by the cells was Na+-dependent, saturable with respect to phosphate, energy-dependent and inhibited by ouabain and arsenate, in agreement with the opera...

Vitamin D was discovered as an anti-rachitic agent preventing a failure in bone mineralization, but it is now established that the active form of vitamin D3 (1α,25(OH)2D3) induces bone resorption. Discovery of the receptor activator of nuclear factor -κB ligand (RANKL) uncovered the molecular mechanism by which 1α,25(OH)2D3 stimulates bone resorption. Treating osteoblastic cells with 1α,25(OH)2...

One of the important categories of subfertility or infertility in humans may be immunological diseases mediated by antisperm antibodies (ASA). Blood sera from 35 infertile men of different age with ASA positive ELISA test were examined for the serum level of ASA before and after treatments with 1,25-dihydroxy-Vitamin-D3 and Dexamethasone. We treated 18 infertile men with VitaminD3/Dexamethason...

Three experiments were conducted to determine whether feeding 25-hydroxyvitamin D3 (25OH D3) or 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3) improves the tenderness of longissimus dorsi (LD), semimembranosus (SM), and infraspinatus (IF) muscles similar to supplemental vitamin D3 without leaving residual vitamin D3 and its metabolites in muscle. In the first two experiments, 24 crossbred steers were...