BACKGROUND Published literature reports significant improvements in pathological conditions, such as pain, blood dyscrasias, and cellulite, after using topical occlusive accessories containing particulate ceramic materials. Recent work reported a reduction in body measurements after 30 days of daily use of high-waist undershorts made of synthetic fabrics with embedded ceramic particles. OBJEC...

BACKGROUND The antifolate edatrexate and the microtubule-stabilizing agent paclitaxel have both demonstrated single-agent activity in lung and breast cancer. In vitro, the sequential combination of edatrexate followed by paclitaxel produced synergistic antitumor effects. This trial was designed to find the maximum tolerated doses of edatrexate and paclitaxel when given every two weeks utilizing...

Pregnant ewes were implanted with 1 g testosterone between days 30-80, 50-100, 70-120 or 90-140 of gestation. Ewes treated between days 30-80 and 50-100 showed increased aggressive behaviour and clitoral enlargement, whereas this was not seen in the day 70-120 or 90-140 groups. Although the implants released similar amounts of testosterone at all stages of gestation, plasma testosterone concent...

We estimated genetic parameters for various phases of body and testicular growth until 550 days of age in Nelore cattle, using Bayesian inference, including correlation values and error estimates. Weight and scrotal records of 54,182 Nelore animals originating from 18 farms participating in the Brazilian Nelore Breeding Program (PMGRN) were included. The following traits were measured: we...

BACKGROUND Propranolol is a drug of choice for many diseases occurring in neonates and infants, an age group for which oral suspensions are required almost exclusively. Many adult and elderly patients for whom propranolol is prescribed are also unable to swallow solid dosage forms. In Canada, propranolol is not commercially available in a liquid dosage form, and existing recipes for extemporane...

In this immunocytochemical study, heterogeneity in the storage of gonadotropins in the sheep fetus was investigated. LH cells were first detected at 50 days of gestation, whereas FSH and LH-FSH cells were observed from Day 89 on; no gonadotropes containing ACTH were observed. LH cell percentage increased for both sexes between 99 and 120 days of gestation (from 2.8 +/- 0.1 to 4.0 +/- 0.3), rema...

Capreomycin was incorporated into multilamellar vesicles of pure dipalmitoylphosphatidylcholine. The pharmacokinetics and nephrotoxicity of capreomycin in the free and liposomal forms were studied in normal mice. The efficacies of the two forms were evaluated by using the Mycobacterium avium complex beige mouse model. Approximately 10(7) viable M. avium cells were injected intravenously. Seven ...

End-stage renal disease (ESRD) patients exhibit an increased incidence of peptic ulcer disease. Helicobacter pylori plays a central role in the development of peptic ulcers. The effect of early H pylori eradication on the recurrence of complicated peptic ulcer disease in ESRD patients remains unclear. The aim of the present study was to explore whether early H pylori eradication therapy in ESRD...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by skeletal muscle atrophy and weakness, ultimately leading to respiratory failure. The purpose of this study was to assess changes in skeletal muscle excitation-contraction (E-C) coupling and intracellular Ca(2+) handling during disease progression in the G93A*SOD1 ALS transgenic (ALS Tg) mouse model. ...