Although Multiple Sclerosis (MS) is regarded as a white matter disease, the incidence of demyelination and axonal injury is prominent also in gray matter. In MS, extracellular adenosine triphosphate (ATP) is an important mediator of central nervous system pathology via its ability to cause oligodendrocyte excitotoxicity. We have analyzed the distribution pattern of all ionotropic P2X and metabo...

This study examined the association between HHV-6 infection and multiple sclerosis (MS) and the relationship between HHV-6 reactivation and disease activity. The frequency of HHV-6 genomic sequences in peripheral blood mononuclear cells (PBMCs), the incidence of plasma viremia (nPCR), the transcription of viral mRNA in PBMCs (RT-PCR), the presence of antiviral IgM and IgG class antibodies in th...

MATERIALS and METHODS Two patients were studied serially: (A) a 19 year old man with clinically definite MS and (B) a 30 year old woman with probable MS (previous episode of optic neuritis 3 months earlier) who both presented with clinical relapses ((A) right hemiparesis; (B) hemianopia, left hemiparesis)). They were studied over 4 months with MRI (on days: (A) 0, 2, 5, 7, 10, 12, 18, 20, 25, 6...

Multiple sclerosis (MS) is an inflammatory disease of the CNS that is associated with demyelination and axonal loss, resulting in severe neurological handicap. Current MS therapies mostly target neuroinflammation but have only a little impact on CNS myelin repair. Progress toward treatments that enhance remyelination would therefore represent major advances in MS treatment. Here, we examined th...

Arachidonate-containing oxidized phospholipids are acutely generated by 12-LOX (12-lipoxygenase) in agonist-activated platelets. In the present study, formation of structurally related lipids by oxidation of DHA (docosahexaenoic acid)-containing phospholipids is demonstrated using lipidomic approaches. Precursor scanning reverse-phase LC (liquid chromatography)-MS/MS (tandem MS) identified a ne...

BACKGROUND Garlic (Allium sativum) has been shown to have important benefits in individuals at high cardiovascular risk. The aim of the present study was to evaluate the effects of the administration of aged garlic extract (AGE) on the risk factors that constitute the cluster of metabolic syndrome (MS). METHODS AND DESIGN Double-blind, crossover, randomized, placebo-controlled clinical trial ...

BACKGROUND The number of steps taken per day (steps/day) provides a reliable and valid outcome of free-living walking behavior in persons with multiple sclerosis (MS). OBJECTIVE This study examined the clinical meaningfulness of steps/day using the minimal clinically important difference (MCID) value across stages representing the developing impact of MS. METHODS This study was a secondary ...

background & aim: multiple sclerosis(ms) is the most common inflammatory disease of central nervous system which is caused by an autoimmune process leading to destruction of myelin sheath. in this disease, cd4+ t–lymphocytes, mostly of th1 phenotype, play important roles in destruction of neuronal tissues.  because of the probable etiologic participation of ebv virus in immunopathogenesis of ms...