Polycyclic aromatic hydrocarbons (PAHs) are immunotoxicants in fish. In mammals, phase I metabolites are believed to be critically involved in the immunotoxicity of PAHs. This mechanism has been suggested for fish as well. The present study investigates the capacity of immune organs (head kidney, spleen) of rainbow trout, Oncorhynchus mykiss, to metabolize the prototypic PAH, benzo [a]pyrene (B...

The pluripotent mammalian epiblast undergoes unusually fast cell proliferation. This rapid growth is expected to generate a high transcriptional demand, but the underlying mechanisms remain unknown. We show here that the chromatin remodeler Chd1 is required for transcriptional output and development of the mouse epiblast. Chd1 embryos exhibit proliferation defects and increased apoptosis, are s...

Spiros Alexakis, Markus Bauer, Albina Pace, Alexa Schumacher CAS Software AG, Wilhelm-Schickard-Str. 10-12, 76131 Karlsruhe, GERMANY [email protected] [email protected] [email protected] [email protected] Andreas Friesen SAP Research, CEC Karlsruhe, Vincenz-Prießnitz-Str. 1, 76131 Karlsruhe, GERMANY [email protected] Athanassios Bouras Institute of Communication and Computer...

Identifying the lemma of a Named Entity is important for many Natural Language Processing applications like Information Retrieval. Here we introduce a novel approach for Named Entity lemmatisation which utilises the occurrence frequencies of each possible lemma. We constructed four corpora in English and Hungarian and trained machine learning methods using them to obtain simple decision rules b...

For five agricultural regions in California, USA, detection frequency of diazinon in surface water and several aspects of its use were determined from recent data (2005-2010): application method, product formulation and primary crops. Diazinon detection frequencies ranged from 10% to 91%. Application method and product formulations used were similar in all regions. The primary crops treated var...

impulsive and convective frequencies are one of the most important subjects for evaluation of the seismic behavior of tanks. these two frequencies are defined by housner and used for obtaining rayleigh damping in time history analysis. aci 350 and nzsee standards have suggested some analytical solutions for finding convective and impulsive frequencies. these frequencies can also extract from mo...

Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed them in insect cells, and assayed their activity as well as the activity of the nine human UGT1As, toward 14 compounds. The goal was to f...

The prevalence of obesity is high in older persons and recent trends show a rapid increase in this prevalence. Results from observational and intervention studies (i.e. weight loss studies) show the strong negative impact of obesity on functional status in old age. There are different potential pathways through which obesity may lead to functional decline in older persons. Furthermore, the pres...

Department of Chemistry, University of Cal E-mail: [email protected]; p_yang@ Howard Hughes Medical Institute, Unive 94720, USA Chemical Sciences Division, Lawrence B California 94720, USA Joint Center for Articial Photosynthesi Laboratory, Berkeley, California 94720, USA Materials Sciences Division, Lawrence B California 94720, USA † Electronic supplementary information (E and structure...

In the dependency pair framework for proving termination of rewriting systems, polynomial interpretations are used to transform dependency chains into bounded decreasing sequences of integers, and they play an important role for the success of proving termination, especially for constrained rewriting systems. In this paper, we show sufficient conditions of linear polynomial interpretations for ...