INTRODUCTION. .................................................................. 488 Description of Drosophila simulans. ................................................ 488 Distribution of Drosophila simulans ................................................ 491 Discovery of Drosophila simulans. ................................................. 491 Drosophila melanogaster 0 X D . simulans 61. ....

Activation of the receptor for advanced glycation endproducts (RAGE) triggers cellular responses implicated in the pathogenesis of diabetic complications; blockade of RAGE has been shown to inhibit the development of diabetic complications. To develop a screening system to identify novel disruptors of advanced glycation endproducts (AGE)-RAGE binding, we used an AGE-RAGE binding system in RAGE-...

Apaf-1 is a central component in the apoptosis regulatory network for the treatment of apoptosis related diseases. Excessive Apaf-1 activity induced by myocardial ischemia causes cell injury. No drug targeted to Apaf-1 for treating myocardial ischemia has been reported to the best of our knowledge. In the present work, we synthesized a novel compound, ZYZ-488, which exhibited significant cardio...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 6.2 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 6.0 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349 7.1 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 488 9.9 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

The PXI (PCI eXtensions for Instrumentation) architecture is relatively new as far as instrumentation standards go. However, in its short history, market acceptance has been excellent. According to estimates from Prime Data in 2002, the PXI market grew 35% in terms of sales and 55% in terms of new product introductions, when compared to 2001 figures. Granted, the market is small when compared t...

BACKGROUND Gout is considered one of the most painful acute conditions caused by deposition of monosodium urate (MSU) crystals within joints. Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanisms of the regulation remain unclear. METHODS A miRNA microa...

We present a device with integrated buried optical waveguides, a microfluidic channel and photodiodes. This device can, for instance, be used as detection unit for absorption measurements on very small volumes (sub nanoliter) of fluid. The fabricated waveguide and diode structures exhibit a low noise equivalent power of 0.5 nW (488 nm, 10 Hz), demonstrating the possibility of using this setup f...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403 5.1 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 494 6.2 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 517 6.5 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 506 6.3 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

Ovary is one of the main endocrine glands, also the source of female fertility and at the same time the organ with the largest number of histological varieties of malignant tumors. The most frequent among primary neoplasms are epithelial tumors. Secondary tumors of the ovary arise by direct tumor extension from adjacent organs or tissues, by transtubal or transperitoneal route, as well as hemat...

The object of this work was to improve the experimental procedure of the superconducting transition lab experiment in the “Modern Physics Laboratory” course. A new method of data acquisition has been implemented. In addition, a GPIB connector has been used to communicate the multimeters with a computer, using Python programming, allowing the direct computerized registering of data, instead of m...