OBJECTIVE To determine the role of monocyte chemoattractant protein-1 (Mcp-1) on the progression of visceral fat-induced atherosclerosis. METHODS AND RESULTS Visceral fat inflammation was induced by transplantation of perigonadal fat. To determine whether recipient Mcp-1 status affected atherosclerosis induced by inflammatory fat, apolipoprotein E-deficient (ApoE(-/-)) and ApoE(-/-) and Mcp-1...

Chemokines are important mediators in infection and inflammation. The monocyte chemotactic proteins (MCPs) form a subclass of structurally related C-C chemokines. MCPs select specific target cells due to binding to a distinct set of chemokine receptors. Recombinant and synthetic MCP-1 variants have been shown to function as chemokine antagonists. In this study, posttranslationally modified immu...

Because of their effects on monocytes, monocyte chemotactic proteins-1 and -2 (MCP-1 and MCP-2) may participate in the pathophysiology of sepsis. We measured circulating MCP-1 and MCP-2 levels in 42 septic patients having positive local or blood cultures. MCP-1 and MCP-2 levels were elevated in 24 (57%) and 25 (59%) of 42 septic patients, respectively, compared with healthy volunteers. Both pat...

The Annurca type is an historical Italian apple fruit probably native to the Campania region. These fruits are harvested before a full maturity stage and go through open-field reddening process. Products based on 1-methylcyclopropene (1-MCP) widely used in postharvest improve quality avoid disorders controlled atmosphere. In this work, we tested impact of 1-MCP traditional system by analyzing t...

atraumatic restorative treatment (art) is a minimal intervention technique in the management of carious lesions, which results in negligible discomfort to the patient. the aim of this study was to assess and compare the discomfort levels during atraumatic restorative treatment and minimal cavity preparation (mcp: a method using rotary instruments) treatment procedures in a sample of school chil...

1-mcp, as an ethylene action inhibitor, significantly delayed the wilting of cut carnation.this study was carried out to determine the optimum concentration and duration of 1-mcp application on vaselife of cut carnation c.v 'tempo'. six levels of 1-mcp concentrations (0,20,40, 60, 80 and 100 nl.1-1) as well as three application times (3, 6 and 9 hours) were studied in a factorial comp...

MCP-1/CCL2 plays an important role in the initiation and progression of cancer. Since tumor cells produce MCP-1, they are considered to be the main source of this chemokine. Here, we examined whether MCP-1 produced by non-tumor cells affects the growth and lung metastasis of 4T1 breast cancer cells by transplanting them into the mammary pad of WT or MCP-1(-/-) mice. Primary tumors at the inject...

Monocyte migration and activation are regulated by monocyte chemoattractant protein-1 (MCP-1). Prior studies have shown MCP-1 expression is modulated by a variety of ligands that act through extracellular receptors. In the current study, we show 9-cis retinoic acid (RA), a ligand for the nuclear hormone receptor retinoid X receptor (RXR) and retinoic acid receptor (RAR), markedly induces the ex...