Tauopathies are neurodegenerative diseases based on pathological tau-aggregation including Alzheimer's disease, frontotemporal dementia (FTD) and Pick's disease. In general, cargo (e.g., β-amyloid precursor protein, tau, neurofilaments) accumulation is a commonly observed phenomenon in degenerated neurons. Therefore, it is crucial to investigate the interaction between cargo, microtubule-bindin...

Cryptosporidium and Giardia are two important pathogenic parasites that have caused many waterborne outbreaks which affected hundreds of thousands of people. Contamination from effluent discharged by sewage treatment plants have been implicated in previous waterborne outbreaks of Cryptosporidium and Giardia. This study evaluated the reduction of Cryptosporidium and Giardia (oo)cysts in two sewa...

Rapamycin is a canonical allosteric inhibitor of the mammalian tarpet of rapamycin (mTOR) kinase with immunosuppressive and proapoptotic activities. We found that in vitro rapamycin also regulates the proteasome, which is an essential intracellular protease of the ubiquitin-proteasome pathway. Rapamycin inhibits proteinase and selected peptidase activities of the catalytic core proteasome at lo...

The objective of the present study is to investigate the relationship between the lesion characteristics of coronary artery and risk factors of coronary heart disease (CHD). A total of 430 patients underwent coronary angiography (CAG) were recruited from January 2008 to October 2009 and divided into CHD group (n=282) and non-CHD group (control group, n=148) according to the findings on CAG. The...

Wire and gate delays are accounted to have equal, or nearly equal, effect on circuit behavior in modern design techniques. This paper introduces a new approach to verify circuits whose behavior is independent of component delays (delay-insensitive). It shows that for a particular way of implementing a delay-insensitive circuit, through a Null Convention Logic methodology, the complexity of the ...