The antiviral activity of 5-methoxymethyl-2'-deoxyuridine (MMUdR) was compared with that of 5-iodo-2'-deoxyuridine (IUdR), cytosine arabinoside (Ara-C), and adenine arabinoside (Ara-A). At concentrations of 2 to 4 mug/ml, MMUdR was inhibitory to herpes simplex virus type 1, but concentrations as high as 128 mug/ml were not inhibitory to three other herpesviruses tested (equine rhinopneumonitis ...

We have studied the relative rate of transcription across the Epstein-Barr virus genome in the Burkitt's lymphoma cell line Raji by nuclear run-on analysis during latency and after induction of an abortive lytic cycle with 12-0-tetradecanoylphorbol 13-acetate (TPA) and 5-iodo-2'-deoxyuridine (IUdR). During latency the entire, or almost the entire, viral genome was found to be transcriptionally ...

The cytotoxicity of 2 rifamycin derivatives, rifazone-82 and rifampicin, on mouse ascites cells was studied, using the [125I]iododeoxyuridine (IUDR) method of labeling the tumor cells. This technique allows a distinction to be made between a cytocidal and cytostatic effect. The 2 drugs exerted a cytocidal effect against 2 non-leukemic cell lines, but had no effect against 3 leukemic lines.

inquired about the evi dence for the absorption of azauridine from the intestine and made the following comments con cerning 5-iododeoxyuridine (IUDR), in view of Szybalski's demonstration of radiosensitization of human cells after their incorporation of IUDR into DNA: â€oeIncollaboration with him and Dr. Kelly Clifton of our Radiology Department we have done some studies in mice with transplan...

Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base damage by DNA mismatch repair (MMR). These coordinated research efforts, sponsored by the National Cancer Institute Integrative Cancer Biology Progr...

introduction: herogeneous proliferative activity of glioma cells (ie non-cycling cells) is on of the main barriers to the therapeutic of radiolabelled iudr. therefore it is important to evaluate the proliferative heterogeneity on iudr theoretical because theoretical calculation suggests that this could be the dominant factor in the efficacy of treatment. materials and methods: the uptake of iud...

We have demonstrated previously an improved therapeutic index for oral 5-iodo-2-deoxypyrimidinone-2'-deoxyribose (IPdR) compared with oral and continuous infusion of 5-iodo-2'-deoxyuridine (IUdR) as a radiosensitizing agent using three different human tumor xenografts in athymic mice. IPdR is a prodrug that is efficiently converted to IUdR by a hepatic aldehyde oxidase, resulting in high IPdR a...

adult periodontitis is a complex multifactorial disease whose etiology is not well defined. the pro-inflammatory and bone resorption properties of interleukine-1α (il-1α) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. eighty iranian adult patients with periodontitis and 80 iranian controls were investigated in this study. in this study we report that the f...

Leu-3- cells that survive infection with the acquired immune deficiency syndrome (AIDS) retrovirus can be induced with IUdR to express infectious virus. A cellular clone (8E5), isolated by limiting dilution of a mass culture of survivor cells, was found to contain a single, integrated provirus that was constitutively expressed. Although IUdR treatment of 8E5 cells failed to induce infectious vi...