Abstract VAL-083 is a novel bi-functional DNA targeting agent that induces inter-strand cross-links at N7-guanine, leading to double-strand breaks and cell death. In vitro in vivo studies have demonstrated circumvents MGMT-mediated chemoresistance differentiates it from other therapies used the treatment of GBM, including temozolomide (TMZ). also acts as radiosensitizer against GBM cancer stem ...

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(1) a. He picked up a pencil, [... ) (W2F-004 #087:1) b. [ ... ) he didn't want me even to pick the child up (S IB-049 #083: I :(3) (2) a. but I'll give him a ring (SIA-058 #084:2:B) b. [ ... ] he gave a similar title to the third collection (S2A-036 #095: I:A) c. [... ) I'll sell up and buy a flat for Emily and myself (W IB-O I0 #072:2) (3) a. Is that from where you get the optic nerve (S IB-O...