1 SFC Research Institute, Keio University, 5322 Endo, Fujisawa 252-8520, Japan 2 Department of Applied Physics, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan 3 Hakodate Campus, Hokkaido University of Education, 1-2 Hachiman-cho, Hakodate 040-8567, Japan 4 Division of Systems and Information Engineering, Graduate School of Engineering, Hok...

1Division of Earth and Planetary Sciences, Graduate School of Science, Hokkaido University, Sapporo, Hokkaido 060-0810, Japan Research Fellow of the Japan Society for the Promotion of Science, Japan 3Division of Natural History Sciences, Graduate School of Science, Hokkaido University, Sapporo, Hokkaido 060-0810, Japan Polar Science Center, Applied Physics Laboratory, University of Washington, ...

OBJECTIVES A new VITEK 2 antibiotic susceptibility testing (AST) card, AST N-054, was introduced for aerobic gram-negative bacilli in 2007 and has been widely adopted for routine use in the UK. We evaluated its performance for detecting extended-spectrum beta-lactamase (ESBL) production in Escherichia coli. METHODS ESBL-producing faecal isolates of E. coli (n = 137) from residents in nursing ...

Hokkaido Institute of Public Health, Sapporo 060-0819; 1School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501; 2Sorachi Public Health and Social Welfare Office, Iwamizawa 068-8558; 3Kamikawa Public Health and Social Welfare Office, Asahikawa 079-8610; 4Iburi Public Health and Social Welfare Office, Muroran 051-8555; 5Department of Health and Welfare, Hokkaido Government, Sapp...

1 Sustainability Governance Project, Creative Research Initiative, Hokkaido University, N9W8, Kita-ku, Sapporo, Hokkaido 060-0809, Japan 2 Graduate School of Environmental Earth Science, Hokkaido University, N10W5, Kita-ku, Sapporo, Hokkaido 060-0810, Japan 3 Frontier Research System for Global Change, 3173-25 Showa-machi, Kanazawa-ku, Yokohama, Kanagawa 236-0001, Japan Received: 13 November 20...

Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan Department of Surgical Pathology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan Correspondence to: Satoru Kase. Department of Ophthalmology, Faculty of Medicine and Graduate School of Med...

Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-kinase Type III and Regulates Viral Propagation Yun-Sook Lim and Soon B. Hwang* From the National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, 431-060, Korea Running head: HCV NS5A modulates PI4KIII * Address correspondence to: Soon B. Hwang, Ph.D. Ilsong Institute o...

Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060, Japan, School of Chemistry, University of Tasmania, GPO Box 252-75, Hobart 7001, Australia, Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060, Japan, National Industrial Research Institute of Nagoya, 1-1 Hirate-cho, Kita-ku, Nagoya 462-8510, Japan, Au...

The clinical efficacy of anti-angiogenic therapies has been difficult to predict, and biomarkers that can predict responsiveness are sorely needed in this era of personalized medicine. CVX-060 is an angiopoietin-2 (Ang2) targeting therapeutic, consisting of two peptides that bind Ang2 with high affinity and specificity, covalently fused to a scaffold antibody. In order to optimize the use of th...

We investigated the mode of the 5-HT3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives, YM060, YM114 (KAE-393), YM-26103-2 and YM-26308-2, against 5-HT-induced transient bradycardia in anesthetized rats. Results were compared with those of ondansetron and granisetron. YM060 (0.03-0.1 microgram/kg, i.v.), YM114 (0.03-0.3 microgram/kg, i.v.), YM-26103-2 (0.01-0.03 microgram/kg, ...