1 UNINOVA and DEE, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Campus da FCT da UNL, Quinta da Torre, 2829-516 Caparica, Portugal 2 INESC ID, Rua Alves Redol, 9, 2o, 1000-029 Lisboa, Portugal 3 L2F INESC ID, Rua Alves Redol, 9, 2o, 1000-029 Lisboa, Portugal 4 Academia Militar, Rua Gomes Freire, 1150-175 Lisboa, Portugal Abstract – In this paper the modeling of Fractional ...

An EOQ model of inventory for items with linear rate of deterioration is considered, taking the demand rate to be dependent on the stocjk level at any instant of time. The Payments are permitted to be delayed up to certain period of time. Shortages are not allowed. After the certain period, a special discount is permitted to reduce the stock in inventory because if the stock is holded, an inter...

Methods Seventy-three patients with FMF and 39 patients with active systemic inflammation due to autoimmune or idiopathic inflammation were evaluated in our reference center for amyloidosis. Mutations in MEFV and the SAA-1 exon 3 variants were analyzed for their contribution to AA risk. Amyloidosis was detected in all cases by congo red staining of kidney or bowel biopsy specimens and AA was cl...

BackgroundProgressive autograft dilation and need for later reoperation remain major concerns of the Ross procedure. The study investigates clinical outcome after operation, including a longitudinal analysis dimensions over 25 years.MethodsFrom November 1991 to April 2019, 137 patients underwent procedure at University Hospitals UCL (Université catholique de Louvain)-Brussels Ghent. Inclusion c...

Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through modulation of neurotransmission at GABA(A) receptors containing alpha1, alpha2, alpha3 or alpha5 subunits, and may have numerous experimental and clinical applications. The ability of non-selective BZ site inverse agonists to enhance cognition, documented in animal mode...

Introduction CINCA syndrome, also known as NOMID, is a rare autoinflammatory disease caused by the NLRP3 mutations. It has been known that conventional genetic analysis failed to detect disease-causing mutations in approximately 40% of patients. We have recently identified NLRP3 somatic mosaicism on 70% of these ”mutation-negative” patients in the international collaborative study (Tanaka N. an...

We study the maximal compact subgroup K(E 9) of the affine Lie group E 9(9) and its on-shell realization as an R symmetry of maximal N = 16 supergravity in two dimensions. We first give a rigorous definition of the group K(E 9), which lives on the double cover of the spectral parameter plane, and show that the infinitesimal action of K(E 9) on the chiral components of the bosons and the fermion...

as its first research and training centre and started work in Helsinki, Finland in 1985. The Institute undertakes applied research and policy analysis on structural changes affecting the developing and transitional economies, provides a forum for the advocacy of policies leading to robust, equitable and environmentally sustainable growth, and promotes capacity strengthening and training in the ...