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Introduction Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is an autosomal dominant autoinflammatory disease caused by mutations in the proline-serinethreonine phosphatase-interacting protein 1, PSTPIP1. The produced protein is a cytoskeleton-associated adaptor protein that modulates T-cell activation, cytoskeletal organization and IL-1b release. The only two mutations desc...
Giant cell arteritis (GCA) is a systemic vasculitis of medium and large vessels. Corticotherapy is the cornerstone treatment, but most patients fail to reach remission or relapse during the weaning of Glucocorticoids (GC). Here we report 2 patients with corticoid dependent GCA, successfully treated with Tocilizumab (TCZ), with a rapid clinical and biological outcome allowing the tapering of GC,...
Fat in the diet of rats. 8 39 carbon dioxide plus soya-bean oil (ratio 2: I) grew poorly, and all died during the first half of the experimental period. 4. The animals fed on a mixture of PT 006 or PT 006 plus distillate-soya-bean oil (ratio 2: I ) grew throughout the whole experimental period (36 weeks), although significantly more slowly than the controls. No neoplastic tissue was found at au...
Does the use of in-stream structures and woody debris increase the abundance of salmonids? CEE review 05-006 (SR12).
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