BACKGROUND Invasive pneumococcal disease (IPD) is an important cause of morbidity among individuals infected with human immunodeficiency virus (HIV). We described incidence and risk factors for IPD in HIV-infected and uninfected individuals. METHODS Nationwide population-based cohort study of HIV-infected adults treated at all Danish HIV treatment centers during 1995-2012. Nineteen population...

Heroin is an illegal drug and monitoring heroin use is important in rehabilitation, pain management services, and workplace employment testing. In humans, heroin is rapidly converted to 6-acetylmorphine (6AM), which is quickly hydrolyzed to morphine. Morphine glucuronide is the major metabolite of heroin in urine (1 ). However, 6AM is a unique metabolite of heroin and is considered the definiti...

Natural History Statistics Older statistics estimate that in the United States, acute pulmonary thromboembolism afflicts 500 000 to 600 000 persons annually and is either a primary or secondary cause of death in 150 000 to 200 000 of these individuals.1,2 Extrapolation of a population-based study from data accumulated in 1985 through 1986 in Worcester, Mass, suggests that each year there are '1...

A method is described for the separation of the outer membrane (OM) from the cytoplasmic membrane (CM) of Pseudomonas cepacia grown in nutrient broth and in chemically defined media under different nutrient depletions. The method is particularly valuable since it is effective when applied to stationary phase cells. Enzyme activities indicated that the contamination of the OM with the CM was les...

An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions with lo...