Background: Exposure to pyrethroids and chlorpyrifos has been previously associated with adverse effects on children’s health. Evidence the human toxicity of glyphosate (GLY) its primary metabolite, aminomethylphosphonic acid (AMPA) is limited, particularly for children. This study aimed i) assess exposure determinants pesticides measured in children Cyprus, ii) determine association between ur...

AMPA receptors mediate the majority of the fast excitatory transmission in the central nervous system. Much evidence suggests that the fast trafficking of AMPA receptors into and out of the postsynaptic membrane underlies changes in synaptic strength thought to be necessary for higher cognitive functions such as learning and memory. Despite the abundance of research conducted in this area, a di...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) unsilencing is an often proposed expression mechanism both for developmental long-term potentiation (LTP), involved in circuitry refinement during brain development, and for mature LTP, involved in learning and memory. In the hippocampal CA3-CA1 connection naïve (nonstimulated) synapses are AMPA signaling and AMPA-silent synapses a...

The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and amino-polyphosphonate degradation. Massive use of the parent compounds leads to the ubiquity of AMPA in the environment, and particularly in water. The purpose of this review is to summarize and discuss current insights into AMPA formation, transport, persistence and toxicity. In agricultura...

The binding of (RS)-alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA), a selective ligand for non-N-methyl-D-aspartate excitatory amino acid receptors, was investigated in rat brain using an autoradiographic receptor binding technique. [3H]AMPA binding sites were widely distributed throughout the rat central nervous system, and the rank order of potency of displacers of [3...

مگس مینوز سبزی و صیفی Liriomyza sativae Blanchard ، از مهم­ترین آفات ‌های گلخانه ای فضای باز، محسوب می شود. با توجه به توصیه کاربرد حشره­ کش تیوسیکلام جهت مدیریت آفت مزبور، در پژوهش حاضر، اثرات کشندگی زیرکشندگی(5/131:LC30، 1/87:LC20، 15/49:LC10 میلی گرم ماده موثره بر لیتر) حشره ­کش (اویسکت®SP50%) روی فراسنجه ­های زیستی این شرایط آزمایشگاهی مورد ارزیابی قرار گرفت. روش استفاده انجام آزمایش­ها غوط...

Both glutamate receptors and transporters are known to be important in the postsynaptic regulation of glutamate neurotransmission. However, the maturation profile of glutamate transporter EAAC1 and glutamate receptor subunits (NR1, NR2A and NR2B; and GluR 1-4) in functionally activated saccule-related vestibular nuclear neurons of postnatal rats remains unclear. In the present study, conscious ...

Both glutamate receptors and transporters are known to be important in the postsynaptic regulation of glutamate neurotransmission. However, the maturation profile of glutamate transporter EAAC1 and glutamate receptor subunits (NR1, NR2A and NR2B; and GluR 1-4) in functionally activated saccule-related vestibular nuclear neurons of postnatal rats remains unclear. In the present study, conscious ...