The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

‎‎in cite{fr 1‎, ‎fr 2} using faithful complex representations of cyclically pinched and conjugacy pinched one-relator groups we proved that any limit group has a faithful representation in $psl(2,c)$‎. ‎further this representation can be effectively constructed using the jsj decomposition‎. ‎in this note we show that any hyperbolic cyclically pinched one-relator group with maximal amalgamated ...

Clive Oppenheimer ISTO, UMR 7327, CNRS/INSU, FR-45071 Orléans, France ISTO, UMR 7327, Université d’Orléans, FR-45071 Orléans, France ISTO, UMR 7327, BRGM, FR-45071 Orléans, France Institute for Advanced Studies, Le Studium, Orléans, France Department of Geography, University of Cambridge, Downing Place, Cambridge CB2 3EN, UK Marina Alletti ISTO, UMR 7327, CNRS/INSU, FR-45071 Orléans, France IST...

Plants exhibit morphological plasticity in response to changes the proportion of far-red radiation (FR). However, little is known about a sudden increase FR component. Cucumber seedlings were acclimatized without (FR-) for 1 - 5 d after germination, and then transferred containing (FR+) at levels similar those natural sunlight. Other FR- or FR+, which was maintained continuously. The damaged co...

The crude polysaccharide extracted from the flowers of burley tobacco hybrid Eyan 1 was fractionated on a Sepharose CL-6B chromatography to get two purified polysaccharide fractions (termed Fr-I and Fr-II). The monocarbohydrate compositions revealed both fractions were heteropolysaccharide. Fr-I was mainly composed of mannose, galactose, ribose and arabinose, while Fr-II was composed of mannose...

Clinical and experimental data suggest that exercise training (ET) and food restriction (FR) improve cardiovascular function. However, the effects of long-term FR or FR in combination with ET on the recovery of cardiac function following ischemia have not been determined. Male Wistar rats were assigned to ad libitum-fed, FR, ad libitum-exercise, and FR-exercise groups. Mechanical function of is...

For Fr$acute{mathbf{text{e}}}$chet algebras $(A, (p_n))$ and $(B, (q_n))$, a linear map $T:Arightarrow B$ is textit{almost multiplicative} with respect to $(p_n)$ and $(q_n)$, if there exists $varepsilongeq 0$ such that $q_n(Tab - Ta Tb)leq varepsilon p_n(a) p_n(b),$ for all $n in mathbb{N}$, $a, b in A$, and it is called textit{weakly almost multiplicative} with respect to $(p_n)$ and $(q_n)$...

Title: Dilemma between health and environmental motives when purchasing animal food products: sociodemographic and nutritional characteristics of consumers Authors: Sandrine Péneau ([email protected]) Philippine Fassier ([email protected]) Benjamin Allès ([email protected]) Emmanuelle Kesse-Guyot ([email protected]) Serge Hercbe...

Fractional repetition (FR) codes are a class of distributed storage codes that replicate and distribute information data over several nodes for easy repair, as well as efficient reconstruction. In this paper, we propose three new constructions of FR codes based on relative difference sets (RDSs) with λ = 1. Specifically, we propose new (q2 − 1, q, q) FR codes using cyclic RDS with parameters (q...

Maternal food restriction (FR) during pregnancy results in intrauterine growth-restricted (IUGR) offspring that show rapid catch-up growth and develop metabolic syndrome and adult obesity. However, continued nutrient restriction during nursing delays catch-up growth and prevents development of obesity. Epigenetic regulation of IGF1, which modulates growth and is synthesized and secreted by the ...