Glutaminyl Cyclase (QC)(2.5.2.3) catalyzes the cyclization of the N-terminal glutamine residues of peptides and proteins. Recent interest in QC has been generated by studies that have linked QC activity in human neuroendocrine tissue to diseases such as Alzheimer’s and osteoporosis. While QC has been isolated and characterized in multiple mammalian species, no attempt has been made to isolate t...

Next-generation sequencing (NGS) technology has revolutionized and significantly impacted metagenomic research. However, the NGS data usually contains sequencing artifacts such as low-quality reads and contaminating reads, which will significantly compromise downstream analysis. Many quality control (QC) tools have been proposed, however, few of them have been verified to be suitable or efficie...

Pyroglutamate-modified Aβ (AβpE3-42) peptides are gaining considerable attention as potential key players in the pathology of Alzheimer disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Overexpressing AβpE3-42 induced a severe neuron loss and neurological phenotype in TBA2 mice. In vitro and in vivo experiments have recently proven t...

BACKGROUND AND AIMS N-truncated pyroglutamate (pGlu)-amyloid-β [Aβ(3-40/42)] peptides are key components that promote Aβ peptide accumulation, leading to neurodegeneration and memory loss in Alzheimer's disease. Because Aβ deposition in the brain occurs in an activity-dependent manner, it is important to define the subcellular organelle for pGlu-Aβ(3-40/42) production by glutaminyl cyclase (QC)...

Staphylococci in Neonates: Does treatment with Linezolid improve outcomes? Ana Chelène Blanchard, MDCM; Céline Laferrière, MD; Isabelle Goyer, Pharm ; Philippe Ovetchkine, MD; Ahmed Moussa, MD; Beatrice Da Silva; Jasmine Swet Yee Chong, BSc Microbiology; Caroline Quach, MDMSc; Department of Pediatrics; Pediatrics, University of Montreal / CHU Sainte Justine, Montreal, QC, Canada; Microbiology, ...

185. Predicting Antimicrobial Resistance Prevalence and Incidence from Indicators of Antimicrobial Use Elise Fortin, PhD(c); Robert W Platt, PhD; Patricia Fontela, MD PhD; David L Buckeridge, MD PhD; Caroline Quach, MD MSc FRCPC; Institut National De Santé Publique Du Québec, Quebec, QC, Canada; Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; Pedia...

The quasicontinuum (QC) method is a spatial multiscale method that extends the length scales accessible to fully atomistic simulations (like molecular dynamics (MD)) by several orders of magnitude. While the recent development of the so-called “hot-QC method” enables dynamic simulations at finite temperature, the times accessible to these simulations remain limited to the sub-microsecond time s...

The number of clinical trials reports is increasing rapidly due to a large number of clinical trials being conducted, it therefore raises an urgent need to utilize the clinical knowledge contained in the clinical trials reports. In this paper, we focus on the qualitative knowledge instead of quantitative knowledge. More precisely, we aim to model and reason with the qualitative comparison (QC f...

Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC, Canada, Groupe de Recherche en Activité Physique Adaptée, Montreal, QC, Canada, Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC, Canada, Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada, Meakins-Chr...

With the advent of the molecular era of plant biology, the location and activity of the quiescent centre (QC) within the root meristem were reappraised with respect to the transport and distribution of hormones, especially auxin. Later, when methods for probing gene activity became established, the genes and their regulators that were identifiably specific to the QC were also actively studied, ...